FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023352200> ?p ?o ?g. }

• W2023352200 endingPage "213" @default.
• W2023352200 startingPage "208" @default.
• W2023352200 abstract "Desmogleins (DSGs) are components of the cell–cell connecting desmosomes. Desmosomal proteins have been found dysregulated in various cancers. Here we studied the role of DSGs in human lung cancer. Expression of DSG1–3 mRNA in lung cancer cell lines and human bronchial epithelial cells (HBEC) was examined by real time RT-PCR. Methylation status of DSG1–2 was evaluated by demethylation test and bisulfite sequencing (BS). Moreover, DSG1–3 protein expression was analysed in 112 primary lung tumor samples by immunohistochemistry (IHC) on tissue microarrays. It turned out that DSG1–3 was downregulated in most of the lung cancer cell lines. Reexpression of DSG2 and DSG3 was found in several cancer cell lines after demethylation treatment with 5-aza-2′-deoxycytidine (DAC), a DNA methyltransferase inhibitor. Complete or partial methylation of DSG2 promoter region was detected in 5 out of 6 cancer cell lines by BS. In primary lung tumors, higher protein expression of DSG2 and DSG3 correlated to the diagnosis of squamous cell lung carcinoma (SCC) (P = 0.009 and P < 0.001, respectively), additionally, a lower expression of DSG3 was significantly linked to higher tumor grade (P = 0.012). Our data suggest that downregulation of DSG2 and DSG3 could be partially explained by DNA methylation. DSG2 and DSG3 might be potential diagnostic markers for SCC, and DSG3 could be a potential differentiation marker for lung cancer." @default.
• W2023352200 created "2016-06-24" @default.
• W2023352200 creator A5020081826 @default.
• W2023352200 creator A5040643126 @default.
• W2023352200 creator A5053464836 @default.
• W2023352200 creator A5083033181 @default.
• W2023352200 creator A5084700217 @default.
• W2023352200 creator A5085615287 @default.
• W2023352200 date "2015-03-01" @default.
• W2023352200 modified "2023-10-16" @default.
• W2023352200 title "Expression of desmogleins 1–3 and their clinical impacts on human lung cancer" @default.
• W2023352200 cites W1770349940 @default.
• W2023352200 cites W190182117 @default.
• W2023352200 cites W1936593340 @default.
• W2023352200 cites W2000493196 @default.
• W2023352200 cites W2002616945 @default.
• W2023352200 cites W2013947848 @default.
• W2023352200 cites W2024156824 @default.
• W2023352200 cites W2033747673 @default.
• W2023352200 cites W2041312245 @default.
• W2023352200 cites W2046551431 @default.
• W2023352200 cites W2054686114 @default.
• W2023352200 cites W2054930937 @default.
• W2023352200 cites W2055734334 @default.
• W2023352200 cites W2087744510 @default.
• W2023352200 cites W2103640192 @default.
• W2023352200 cites W2129656350 @default.
• W2023352200 cites W2137280750 @default.
• W2023352200 cites W2145653040 @default.
• W2023352200 cites W2153954383 @default.
• W2023352200 cites W2160949062 @default.
• W2023352200 cites W2161618203 @default.
• W2023352200 doi "https://doi.org/10.1016/j.prp.2014.10.008" @default.
• W2023352200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25468811" @default.
• W2023352200 hasPublicationYear "2015" @default.
• W2023352200 type Work @default.
• W2023352200 sameAs 2023352200 @default.
• W2023352200 citedByCount "29" @default.
• W2023352200 countsByYear W20233522002015 @default.
• W2023352200 countsByYear W20233522002016 @default.
• W2023352200 countsByYear W20233522002017 @default.
• W2023352200 countsByYear W20233522002018 @default.
• W2023352200 countsByYear W20233522002019 @default.
• W2023352200 countsByYear W20233522002020 @default.
• W2023352200 countsByYear W20233522002021 @default.
• W2023352200 countsByYear W20233522002022 @default.
• W2023352200 countsByYear W20233522002023 @default.
• W2023352200 crossrefType "journal-article" @default.
• W2023352200 hasAuthorship W2023352200A5020081826 @default.
• W2023352200 hasAuthorship W2023352200A5040643126 @default.
• W2023352200 hasAuthorship W2023352200A5053464836 @default.
• W2023352200 hasAuthorship W2023352200A5083033181 @default.
• W2023352200 hasAuthorship W2023352200A5084700217 @default.
• W2023352200 hasAuthorship W2023352200A5085615287 @default.
• W2023352200 hasConcept C104317684 @default.
• W2023352200 hasConcept C121608353 @default.
• W2023352200 hasConcept C142724271 @default.
• W2023352200 hasConcept C1491633281 @default.
• W2023352200 hasConcept C149402561 @default.
• W2023352200 hasConcept C150194340 @default.
• W2023352200 hasConcept C153911025 @default.
• W2023352200 hasConcept C159654299 @default.
• W2023352200 hasConcept C189235521 @default.
• W2023352200 hasConcept C190727270 @default.
• W2023352200 hasConcept C203014093 @default.
• W2023352200 hasConcept C204232928 @default.
• W2023352200 hasConcept C2776256026 @default.
• W2023352200 hasConcept C2779075594 @default.
• W2023352200 hasConcept C2909223747 @default.
• W2023352200 hasConcept C33288867 @default.
• W2023352200 hasConcept C502942594 @default.
• W2023352200 hasConcept C54355233 @default.
• W2023352200 hasConcept C67326383 @default.
• W2023352200 hasConcept C71924100 @default.
• W2023352200 hasConcept C86803240 @default.
• W2023352200 hasConceptScore W2023352200C104317684 @default.
• W2023352200 hasConceptScore W2023352200C121608353 @default.
• W2023352200 hasConceptScore W2023352200C142724271 @default.
• W2023352200 hasConceptScore W2023352200C1491633281 @default.
• W2023352200 hasConceptScore W2023352200C149402561 @default.
• W2023352200 hasConceptScore W2023352200C150194340 @default.
• W2023352200 hasConceptScore W2023352200C153911025 @default.
• W2023352200 hasConceptScore W2023352200C159654299 @default.
• W2023352200 hasConceptScore W2023352200C189235521 @default.
• W2023352200 hasConceptScore W2023352200C190727270 @default.
• W2023352200 hasConceptScore W2023352200C203014093 @default.
• W2023352200 hasConceptScore W2023352200C204232928 @default.
• W2023352200 hasConceptScore W2023352200C2776256026 @default.
• W2023352200 hasConceptScore W2023352200C2779075594 @default.
• W2023352200 hasConceptScore W2023352200C2909223747 @default.
• W2023352200 hasConceptScore W2023352200C33288867 @default.
• W2023352200 hasConceptScore W2023352200C502942594 @default.
• W2023352200 hasConceptScore W2023352200C54355233 @default.
• W2023352200 hasConceptScore W2023352200C67326383 @default.
• W2023352200 hasConceptScore W2023352200C71924100 @default.
• W2023352200 hasConceptScore W2023352200C86803240 @default.
• W2023352200 hasFunder F4320323556 @default.
• W2023352200 hasIssue "3" @default.

• next