FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023352519> ?p ?o ?g. }

• W2023352519 endingPage "4883" @default.
• W2023352519 startingPage "4876" @default.
• W2023352519 abstract "The FE65 gene encodes a nuclear protein of unknown function that is expressed in several areas of the rat nervous system during development and in the adult animal, particularly in somatic and visceral ganglia. FE65 mRNA is abundant in neuronal cell lines, whereas it is barely detectable in non-neuronal cells. We identified the two transcription start sites of the FE65 gene and we isolated the rat genomic fragment containing one of these two transcriptional start sites. We demonstrate that this fragment contains a promoter able to direct an efficient transcription of a reporter gene in PC12 cells and in NTERA2 cells upon their differentiation with retinoic acid, whereas it functions poorly in non-neuronal cells, such as Rat2 fibroblasts and BRL hepatocytes. This promoter is composed of two regions. The first includes a cis-element whose removal greatly decreases the transcriptional efficiency in all cells examined and which forms similar complexes with proteins from PC12 and Rat2 cells. This cis-element binds Sp1 or another GC-binding factor. The second cis-element encompasses the transcription start site and is still able to direct transcription only in neuronal cells. The DNA-protein complexes formed by this cis-element in neuronal cells differ from those formed in non-neuronal cells. The analysis of point mutations in this region indicates that the proteins that bind to this cis-element interact with both overlapping and distinct nucleotide sequences." @default.
• W2023352519 created "2016-06-24" @default.
• W2023352519 creator A5027661180 @default.
• W2023352519 creator A5054781081 @default.
• W2023352519 creator A5055286766 @default.
• W2023352519 creator A5057208932 @default.
• W2023352519 creator A5061223397 @default.
• W2023352519 creator A5087868901 @default.
• W2023352519 date "1994-01-01" @default.
• W2023352519 modified "2023-09-26" @default.
• W2023352519 title "The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription" @default.
• W2023352519 cites W111930704 @default.
• W2023352519 cites W1561101579 @default.
• W2023352519 cites W1647688145 @default.
• W2023352519 cites W1691146464 @default.
• W2023352519 cites W1806844342 @default.
• W2023352519 cites W1809219653 @default.
• W2023352519 cites W1932076246 @default.
• W2023352519 cites W1966156883 @default.
• W2023352519 cites W1975987535 @default.
• W2023352519 cites W1980807416 @default.
• W2023352519 cites W1982540383 @default.
• W2023352519 cites W1994569164 @default.
• W2023352519 cites W1999156595 @default.
• W2023352519 cites W2000148292 @default.
• W2023352519 cites W2005452949 @default.
• W2023352519 cites W2012418253 @default.
• W2023352519 cites W2030213745 @default.
• W2023352519 cites W2038192335 @default.
• W2023352519 cites W2049862742 @default.
• W2023352519 cites W2066441904 @default.
• W2023352519 cites W2073350856 @default.
• W2023352519 cites W2074351361 @default.
• W2023352519 cites W2085361948 @default.
• W2023352519 cites W2088577765 @default.
• W2023352519 cites W2138270253 @default.
• W2023352519 cites W2146321419 @default.
• W2023352519 cites W2150295206 @default.
• W2023352519 doi "https://doi.org/10.1093/nar/22.23.4876" @default.
• W2023352519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/523751" @default.
• W2023352519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7800475" @default.
• W2023352519 hasPublicationYear "1994" @default.
• W2023352519 type Work @default.
• W2023352519 sameAs 2023352519 @default.
• W2023352519 citedByCount "26" @default.
• W2023352519 countsByYear W20233525192015 @default.
• W2023352519 crossrefType "journal-article" @default.
• W2023352519 hasAuthorship W2023352519A5027661180 @default.
• W2023352519 hasAuthorship W2023352519A5054781081 @default.
• W2023352519 hasAuthorship W2023352519A5055286766 @default.
• W2023352519 hasAuthorship W2023352519A5057208932 @default.
• W2023352519 hasAuthorship W2023352519A5061223397 @default.
• W2023352519 hasAuthorship W2023352519A5087868901 @default.
• W2023352519 hasBestOaLocation W20233525192 @default.
• W2023352519 hasConcept C101762097 @default.
• W2023352519 hasConcept C104317684 @default.
• W2023352519 hasConcept C132376346 @default.
• W2023352519 hasConcept C138885662 @default.
• W2023352519 hasConcept C144825837 @default.
• W2023352519 hasConcept C150194340 @default.
• W2023352519 hasConcept C153911025 @default.
• W2023352519 hasConcept C161733203 @default.
• W2023352519 hasConcept C179926584 @default.
• W2023352519 hasConcept C41895202 @default.
• W2023352519 hasConcept C54355233 @default.
• W2023352519 hasConcept C65888428 @default.
• W2023352519 hasConcept C76753757 @default.
• W2023352519 hasConcept C86339819 @default.
• W2023352519 hasConcept C86803240 @default.
• W2023352519 hasConcept C95444343 @default.
• W2023352519 hasConceptScore W2023352519C101762097 @default.
• W2023352519 hasConceptScore W2023352519C104317684 @default.
• W2023352519 hasConceptScore W2023352519C132376346 @default.
• W2023352519 hasConceptScore W2023352519C138885662 @default.
• W2023352519 hasConceptScore W2023352519C144825837 @default.
• W2023352519 hasConceptScore W2023352519C150194340 @default.
• W2023352519 hasConceptScore W2023352519C153911025 @default.
• W2023352519 hasConceptScore W2023352519C161733203 @default.
• W2023352519 hasConceptScore W2023352519C179926584 @default.
• W2023352519 hasConceptScore W2023352519C41895202 @default.
• W2023352519 hasConceptScore W2023352519C54355233 @default.
• W2023352519 hasConceptScore W2023352519C65888428 @default.
• W2023352519 hasConceptScore W2023352519C76753757 @default.
• W2023352519 hasConceptScore W2023352519C86339819 @default.
• W2023352519 hasConceptScore W2023352519C86803240 @default.
• W2023352519 hasConceptScore W2023352519C95444343 @default.
• W2023352519 hasIssue "23" @default.
• W2023352519 hasLocation W20233525191 @default.
• W2023352519 hasLocation W20233525192 @default.
• W2023352519 hasLocation W20233525193 @default.
• W2023352519 hasLocation W20233525194 @default.
• W2023352519 hasOpenAccess W2023352519 @default.
• W2023352519 hasPrimaryLocation W20233525191 @default.
• W2023352519 hasRelatedWork W1707517094 @default.
• W2023352519 hasRelatedWork W1982887948 @default.
• W2023352519 hasRelatedWork W2005916961 @default.
• W2023352519 hasRelatedWork W2020299722 @default.
• W2023352519 hasRelatedWork W2065830290 @default.

• next