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- W2023352684 abstract "• Topical antimicrobial therapy has not been effective in the past against cutaneous bacterial infections. In this study, a new topical antibiotic ointment, mupirocin, was compared with oral erythromycin ethylsuccinate in the treatment of impetigo. Seventy-five patients clinically diagnosed as having impetigo and with positive cultures of<i>Staphylococcus aureus, Streptococcus pyogenes</i>, or both were examined in an investigator-blinded study. Patients used topical mupirocin applied three times daily or the usual oral dose of erythromycin ethylsuccinate (30 to 50 mg/kg per day). Patients' lesions were examined clinically and cultured bacteriologically on days 0, 3, and 8, and 1 week after treatment. Susceptibility testing was performed on pathogens isolated to determine antibiotic resistance. Mupirocin treatment produced similar clinical results to oral erythromycin and was superior in the eradication of<i>S aureus</i>, including antibiotic-resistant<i>S aureus</i>. These results show topical mupirocin to be a safe and effective alternative to oral antibiotic therapy in the treatment of impetigo. (<i>Arch Dermatol.</i>1989;125:1069-1073)" @default.
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- W2023352684 date "1989-08-01" @default.
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- W2023352684 title "Topical Mupirocin Treatment of Impetigo Is Equal to Oral Erythromycin Therapy" @default.
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- W2023352684 doi "https://doi.org/10.1001/archderm.1989.01670200045006" @default.
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