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• W2023353015 endingPage "S59" @default.
• W2023353015 startingPage "S53" @default.
• W2023353015 abstract "Evidence suggests the involvement of growth hormone (GH), insulin-like growth factor I (IGF-I) and somatostatin in the pathology associated with diabetic retinopathy. We examined the effect of IGF-I on human retinal endothelial cell (HREC) survival following high glucose exposure and serum starvation, examined the signalling pathways mediating the protective effect of IGF-I on HREC, and characterized somatostatin receptor-induced retinal endothelial cell death. IGF-I (10 ng/ml) protected HREC from apoptosis induced by high glucose and serum starvation. Wortmannin, a specific inhibitor of phosphotidylinositol-3-kinase, blocks the ability of IGF-I to protect HREC from apoptosis. Incubation of HREC in serum-free medium caused a time-dependent increase in c-Jun N-terminal kinase (JNK) activity, and continuous culture of HREC in the presence of IGF-I or vascular endothelial growth factor (VEGF) prevented JNK activation and arrested apoptosis. Activation of tyrosine kinase receptors results in extracellular signal-related kinase (ERK) activation and activation of ERK is required for proliferation. Both IGF-I and VEGF produced a time- and concentration-dependent increase in the activation of ERK. Type 2 and type 3 somatostatin receptors have been implicated in cell-cycle arrest and apoptosis. Activation of the type 3 receptor in HREC resulted in cell death. These studies suggest that IGF-I is critical for HREC survival, and that somatostatin analogues acting through the type 3 receptor have direct effects on retinal endothelial cells. Furthermore, it appears that the therapeutic efficacy of somatostatin analogues lies not only in systemic inhibition of GH, but also in modulating local growth factor effects." @default.
• W2023353015 created "2016-06-24" @default.
• W2023353015 creator A5081226225 @default.
• W2023353015 creator A5082944792 @default.
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• W2023353015 date "2001-06-01" @default.
• W2023353015 modified "2023-10-06" @default.
• W2023353015 title "Modulation of retinal endothelial cell behaviour by insulin-like growth factor 1 and somatostatin analogues: Implications for diabetic retinopathy" @default.
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• W2023353015 doi "https://doi.org/10.1016/s1096-6374(01)80009-5" @default.
• W2023353015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11527089" @default.
• W2023353015 hasPublicationYear "2001" @default.
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