Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023353142> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2023353142 endingPage "1561" @default.
- W2023353142 startingPage "1551" @default.
- W2023353142 abstract "Abstract Since interferon-alfa (IFN-α) and Sho-saiko-to (SST) are known to modulate immune responses, their immunological effects may be responsible for the induction of interstitial pneumonia. Additionally, fibroblasts play an important role in lung fibrosis. Therefore, the in vitro effects of IFN-α and/or SST on cytokine production of fibroblasts were examined. No difference in cytokine production was shown among natural IFN-α, IFN-α-2a, and IFN-α-2b. Fibroblasts from three control subjects and four patients with idiopathic pulmonary fibrosis (IPF) were used. Cells from the control and IPF groups produced interleukin-6 (IL-6) dose-dependently with either IFN-α or SST treatment. Combined administration of these agents produced greater IL-6 production. In all controls, interleukin-8 (IL-8) production by fibroblasts was increased with SST but suppressed with IFN-α. In contrast, in 2 of 4 IPF patients, IL-8 production was increased with IFN-α. More importantly, there was a greater production of IL-8 when stimulated with both IFN-α and SST in the IPF group. Proliferation of control and IPF fibroblasts was inhibited equally by each drug. These results suggest that fibroblast cytokine production, augmented by IFN-α and/or SST, may play a role in the development or exacerbation of interstitial pneumonia." @default.
- W2023353142 created "2016-06-24" @default.
- W2023353142 creator A5034160788 @default.
- W2023353142 creator A5053510533 @default.
- W2023353142 creator A5080476910 @default.
- W2023353142 creator A5089141929 @default.
- W2023353142 date "1994-12-01" @default.
- W2023353142 modified "2023-09-27" @default.
- W2023353142 title "Effects of interferon-alfa and the herbal medicine Sho-saiko-to on cytokine production and lung fibroblast proliferation" @default.
- W2023353142 cites W1937560614 @default.
- W2023353142 cites W1965091080 @default.
- W2023353142 cites W1973409404 @default.
- W2023353142 cites W1973652991 @default.
- W2023353142 cites W1984044364 @default.
- W2023353142 cites W1993884809 @default.
- W2023353142 cites W1998255684 @default.
- W2023353142 cites W2001108794 @default.
- W2023353142 cites W2014788180 @default.
- W2023353142 cites W2047377654 @default.
- W2023353142 cites W2066612615 @default.
- W2023353142 cites W2080885631 @default.
- W2023353142 cites W2082989553 @default.
- W2023353142 cites W2103401040 @default.
- W2023353142 cites W2141779237 @default.
- W2023353142 cites W2332576710 @default.
- W2023353142 cites W4245868295 @default.
- W2023353142 doi "https://doi.org/10.1016/s0011-393x(05)80763-5" @default.
- W2023353142 hasPublicationYear "1994" @default.
- W2023353142 type Work @default.
- W2023353142 sameAs 2023353142 @default.
- W2023353142 citedByCount "8" @default.
- W2023353142 countsByYear W20233531422012 @default.
- W2023353142 countsByYear W20233531422016 @default.
- W2023353142 countsByYear W20233531422017 @default.
- W2023353142 countsByYear W20233531422022 @default.
- W2023353142 crossrefType "journal-article" @default.
- W2023353142 hasAuthorship W2023353142A5034160788 @default.
- W2023353142 hasAuthorship W2023353142A5053510533 @default.
- W2023353142 hasAuthorship W2023353142A5080476910 @default.
- W2023353142 hasAuthorship W2023353142A5089141929 @default.
- W2023353142 hasConcept C126322002 @default.
- W2023353142 hasConcept C203014093 @default.
- W2023353142 hasConcept C2776178377 @default.
- W2023353142 hasConcept C2777714996 @default.
- W2023353142 hasConcept C2778690821 @default.
- W2023353142 hasConcept C2780381497 @default.
- W2023353142 hasConcept C502942594 @default.
- W2023353142 hasConcept C54355233 @default.
- W2023353142 hasConcept C556039675 @default.
- W2023353142 hasConcept C71924100 @default.
- W2023353142 hasConcept C81885089 @default.
- W2023353142 hasConcept C86803240 @default.
- W2023353142 hasConceptScore W2023353142C126322002 @default.
- W2023353142 hasConceptScore W2023353142C203014093 @default.
- W2023353142 hasConceptScore W2023353142C2776178377 @default.
- W2023353142 hasConceptScore W2023353142C2777714996 @default.
- W2023353142 hasConceptScore W2023353142C2778690821 @default.
- W2023353142 hasConceptScore W2023353142C2780381497 @default.
- W2023353142 hasConceptScore W2023353142C502942594 @default.
- W2023353142 hasConceptScore W2023353142C54355233 @default.
- W2023353142 hasConceptScore W2023353142C556039675 @default.
- W2023353142 hasConceptScore W2023353142C71924100 @default.
- W2023353142 hasConceptScore W2023353142C81885089 @default.
- W2023353142 hasConceptScore W2023353142C86803240 @default.
- W2023353142 hasIssue "12" @default.
- W2023353142 hasLocation W20233531421 @default.
- W2023353142 hasOpenAccess W2023353142 @default.
- W2023353142 hasPrimaryLocation W20233531421 @default.
- W2023353142 hasRelatedWork W1606529214 @default.
- W2023353142 hasRelatedWork W1984364643 @default.
- W2023353142 hasRelatedWork W1986234548 @default.
- W2023353142 hasRelatedWork W2027570319 @default.
- W2023353142 hasRelatedWork W2160010097 @default.
- W2023353142 hasRelatedWork W2420746378 @default.
- W2023353142 hasRelatedWork W2746064660 @default.
- W2023353142 hasRelatedWork W2969215868 @default.
- W2023353142 hasRelatedWork W3005652238 @default.
- W2023353142 hasRelatedWork W4232898603 @default.
- W2023353142 hasVolume "55" @default.
- W2023353142 isParatext "false" @default.
- W2023353142 isRetracted "false" @default.
- W2023353142 magId "2023353142" @default.
- W2023353142 workType "article" @default.