FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023353218> ?p ?o ?g. }

• W2023353218 endingPage "47" @default.
• W2023353218 startingPage "37" @default.
• W2023353218 abstract "5-lipoxygenase (5LO) catalyzes formation of leukotrienes, mediators with roles in several inflammatory disorders, including atherosclerosis. The human 5LO gene promoter contain multiple GC-boxes. The relevance of these for expression of 5LO in the human monocytic cell line Mono Mac 6 (MM6) was studied. A downregulating effect of the GC-box binding compound mithramycin indicated that GC-rich sequences in the 5LO gene promoter are important for expression of native 5LO. In DNase I footprinting, mithramycin and Sp1 protected known GC-boxes, but also a novel Sp1 binding site was found, comprising 20 bp upstream of the major transcription initiation site, beside an Initiator-like sequence. Mutation of this site reduced Sp1 binding and expression of reporter genes in MM6 cells, compatible with a function as basal promoter element for the TATA-less 5LO gene. When differentiation was induced by TGFbeta and vitamin D(3), 5LO expression became prominent, but expression levels of Sp1/3 and Egr-1 were the same as for control cells. Also, 5LO reporter gene activity in transiently transfected MM6 cells was insensitive to differentiation. Thus, the GC-rich part of the 5LO gene promoter, including a novel Sp1 site, appear important for basal (rather than upregulated) transcription of 5LO in MM6 cells." @default.
• W2023353218 created "2016-06-24" @default.
• W2023353218 creator A5022383909 @default.
• W2023353218 creator A5045395183 @default.
• W2023353218 creator A5054559822 @default.
• W2023353218 creator A5068475956 @default.
• W2023353218 creator A5073127821 @default.
• W2023353218 creator A5082078699 @default.
• W2023353218 creator A5082257614 @default.
• W2023353218 date "2005-12-30" @default.
• W2023353218 modified "2023-10-05" @default.
• W2023353218 title "GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site" @default.
• W2023353218 cites W1544939802 @default.
• W2023353218 cites W1848987069 @default.
• W2023353218 cites W1963981548 @default.
• W2023353218 cites W1966576495 @default.
• W2023353218 cites W1976217481 @default.
• W2023353218 cites W1991469067 @default.
• W2023353218 cites W1995529555 @default.
• W2023353218 cites W1999966058 @default.
• W2023353218 cites W2000771735 @default.
• W2023353218 cites W2004942960 @default.
• W2023353218 cites W2010160611 @default.
• W2023353218 cites W2011369010 @default.
• W2023353218 cites W2020427232 @default.
• W2023353218 cites W2024176341 @default.
• W2023353218 cites W2035093916 @default.
• W2023353218 cites W2047897365 @default.
• W2023353218 cites W2050078665 @default.
• W2023353218 cites W2051183422 @default.
• W2023353218 cites W2052956732 @default.
• W2023353218 cites W2061869584 @default.
• W2023353218 cites W2066650638 @default.
• W2023353218 cites W2071978198 @default.
• W2023353218 cites W2075867996 @default.
• W2023353218 cites W2077169693 @default.
• W2023353218 cites W2083490046 @default.
• W2023353218 cites W2087358019 @default.
• W2023353218 cites W2090578197 @default.
• W2023353218 cites W2092136133 @default.
• W2023353218 cites W2095612833 @default.
• W2023353218 cites W2099960599 @default.
• W2023353218 cites W2101332831 @default.
• W2023353218 cites W2106169455 @default.
• W2023353218 cites W2126155308 @default.
• W2023353218 cites W2132989642 @default.
• W2023353218 cites W2140901513 @default.
• W2023353218 cites W2143425888 @default.
• W2023353218 cites W2146090466 @default.
• W2023353218 cites W2155978222 @default.
• W2023353218 cites W2164615751 @default.
• W2023353218 cites W2171553772 @default.
• W2023353218 cites W484044683 @default.
• W2023353218 doi "https://doi.org/10.1016/j.bbalip.2005.11.008" @default.
• W2023353218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16413224" @default.
• W2023353218 hasPublicationYear "2005" @default.
• W2023353218 type Work @default.
• W2023353218 sameAs 2023353218 @default.
• W2023353218 citedByCount "24" @default.
• W2023353218 countsByYear W20233532182012 @default.
• W2023353218 countsByYear W20233532182013 @default.
• W2023353218 countsByYear W20233532182014 @default.
• W2023353218 countsByYear W20233532182015 @default.
• W2023353218 countsByYear W20233532182016 @default.
• W2023353218 countsByYear W20233532182017 @default.
• W2023353218 countsByYear W20233532182020 @default.
• W2023353218 countsByYear W20233532182022 @default.
• W2023353218 crossrefType "journal-article" @default.
• W2023353218 hasAuthorship W2023353218A5022383909 @default.
• W2023353218 hasAuthorship W2023353218A5045395183 @default.
• W2023353218 hasAuthorship W2023353218A5054559822 @default.
• W2023353218 hasAuthorship W2023353218A5068475956 @default.
• W2023353218 hasAuthorship W2023353218A5073127821 @default.
• W2023353218 hasAuthorship W2023353218A5082078699 @default.
• W2023353218 hasAuthorship W2023353218A5082257614 @default.
• W2023353218 hasConcept C101762097 @default.
• W2023353218 hasConcept C104317684 @default.
• W2023353218 hasConcept C107824862 @default.
• W2023353218 hasConcept C138885662 @default.
• W2023353218 hasConcept C150194340 @default.
• W2023353218 hasConcept C153911025 @default.
• W2023353218 hasConcept C161733203 @default.
• W2023353218 hasConcept C179716448 @default.
• W2023353218 hasConcept C179926584 @default.
• W2023353218 hasConcept C181199279 @default.
• W2023353218 hasConcept C2778078955 @default.
• W2023353218 hasConcept C41895202 @default.
• W2023353218 hasConcept C54009773 @default.
• W2023353218 hasConcept C54355233 @default.
• W2023353218 hasConcept C55493867 @default.
• W2023353218 hasConcept C65888428 @default.
• W2023353218 hasConcept C86339819 @default.
• W2023353218 hasConcept C86803240 @default.
• W2023353218 hasConcept C90342290 @default.
• W2023353218 hasConceptScore W2023353218C101762097 @default.
• W2023353218 hasConceptScore W2023353218C104317684 @default.
• W2023353218 hasConceptScore W2023353218C107824862 @default.
• W2023353218 hasConceptScore W2023353218C138885662 @default.

• next