Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023354986> ?p ?o ?g. }
- W2023354986 abstract "Viral central nervous system (CNS) infections are common in countries where malaria is endemic but, due to limited laboratory facilities, few studies have systematically examined the prevalence and clinical consequences of the presence of viruses in cerebrospinal fluid (CSF) from children with suspected CNS infection. We performed a prospective study of Papua New Guinean children hospitalized with signs and symptoms of CNS infection. CSF samples from 300 children without proven bacterial/fungal meningitis were analyzed for human herpes viruses (HHV), picornaviruses, influenza, adenoviruses, flaviviruses and bacteria. Fifty-five children (18%) had viral (42), bacterial (20) or both viral and bacterial (7) nucleic acids (NA) identified in their CSF. Human herpes viruses accounted for 91% of all viruses found. The identification of viral or bacterial NA was not associated with any characteristic clinical features. By contrast, malaria was associated with increased identification of viral and bacterial NA and with impaired consciousness, multiple convulsions and age. Malaria was also inversely associated with an adverse outcome. Amongst children with HHV infection, those with HHV-6 and −7 were younger, were more likely have impaired consciousness and had a higher proportion of adverse outcomes than children with CMV. Dengue and enteroviral infections were infrequent. Adenoviral and influenza infections were not identified. Infections with HHV-6, HHV-7, dengue and enterovirus have the potential to cause serious CNS disease in young PNG children. However most HHVs in this malaria-endemic setting should be considered to be the result of reactivation from a latent reservoir without clinical sequelae." @default.
- W2023354986 created "2016-06-24" @default.
- W2023354986 creator A5011734446 @default.
- W2023354986 creator A5016134527 @default.
- W2023354986 creator A5020890152 @default.
- W2023354986 creator A5024369380 @default.
- W2023354986 creator A5040081397 @default.
- W2023354986 creator A5042950510 @default.
- W2023354986 creator A5043426673 @default.
- W2023354986 creator A5047879680 @default.
- W2023354986 creator A5073166591 @default.
- W2023354986 creator A5082061848 @default.
- W2023354986 creator A5084635606 @default.
- W2023354986 creator A5091071864 @default.
- W2023354986 date "2014-11-26" @default.
- W2023354986 modified "2023-10-06" @default.
- W2023354986 title "Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea" @default.
- W2023354986 cites W1898668028 @default.
- W2023354986 cites W1928373920 @default.
- W2023354986 cites W1969790923 @default.
- W2023354986 cites W1971497078 @default.
- W2023354986 cites W1991323583 @default.
- W2023354986 cites W2002328194 @default.
- W2023354986 cites W2004195154 @default.
- W2023354986 cites W2012721575 @default.
- W2023354986 cites W2014154272 @default.
- W2023354986 cites W2022365636 @default.
- W2023354986 cites W2034459005 @default.
- W2023354986 cites W2061097205 @default.
- W2023354986 cites W2071063700 @default.
- W2023354986 cites W2071113348 @default.
- W2023354986 cites W2090182505 @default.
- W2023354986 cites W2090613637 @default.
- W2023354986 cites W2103262674 @default.
- W2023354986 cites W2113958321 @default.
- W2023354986 cites W2115669202 @default.
- W2023354986 cites W2136042143 @default.
- W2023354986 cites W2147685557 @default.
- W2023354986 cites W2154953108 @default.
- W2023354986 cites W2156628079 @default.
- W2023354986 cites W2158261782 @default.
- W2023354986 cites W2158864742 @default.
- W2023354986 cites W2162387779 @default.
- W2023354986 cites W2163848440 @default.
- W2023354986 cites W2168804622 @default.
- W2023354986 cites W2169918301 @default.
- W2023354986 cites W2332065169 @default.
- W2023354986 doi "https://doi.org/10.1186/s12879-014-0630-0" @default.
- W2023354986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4260243" @default.
- W2023354986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25423900" @default.
- W2023354986 hasPublicationYear "2014" @default.
- W2023354986 type Work @default.
- W2023354986 sameAs 2023354986 @default.
- W2023354986 citedByCount "7" @default.
- W2023354986 countsByYear W20233549862015 @default.
- W2023354986 countsByYear W20233549862016 @default.
- W2023354986 countsByYear W20233549862017 @default.
- W2023354986 countsByYear W20233549862018 @default.
- W2023354986 countsByYear W20233549862020 @default.
- W2023354986 crossrefType "journal-article" @default.
- W2023354986 hasAuthorship W2023354986A5011734446 @default.
- W2023354986 hasAuthorship W2023354986A5016134527 @default.
- W2023354986 hasAuthorship W2023354986A5020890152 @default.
- W2023354986 hasAuthorship W2023354986A5024369380 @default.
- W2023354986 hasAuthorship W2023354986A5040081397 @default.
- W2023354986 hasAuthorship W2023354986A5042950510 @default.
- W2023354986 hasAuthorship W2023354986A5043426673 @default.
- W2023354986 hasAuthorship W2023354986A5047879680 @default.
- W2023354986 hasAuthorship W2023354986A5073166591 @default.
- W2023354986 hasAuthorship W2023354986A5082061848 @default.
- W2023354986 hasAuthorship W2023354986A5084635606 @default.
- W2023354986 hasAuthorship W2023354986A5091071864 @default.
- W2023354986 hasBestOaLocation W20233549861 @default.
- W2023354986 hasConcept C159047783 @default.
- W2023354986 hasConcept C187212893 @default.
- W2023354986 hasConcept C190139176 @default.
- W2023354986 hasConcept C203014093 @default.
- W2023354986 hasConcept C2777208983 @default.
- W2023354986 hasConcept C2778048844 @default.
- W2023354986 hasConcept C2778621254 @default.
- W2023354986 hasConcept C2779635636 @default.
- W2023354986 hasConcept C2781026528 @default.
- W2023354986 hasConcept C3018430615 @default.
- W2023354986 hasConcept C533803919 @default.
- W2023354986 hasConcept C71924100 @default.
- W2023354986 hasConcept C86803240 @default.
- W2023354986 hasConceptScore W2023354986C159047783 @default.
- W2023354986 hasConceptScore W2023354986C187212893 @default.
- W2023354986 hasConceptScore W2023354986C190139176 @default.
- W2023354986 hasConceptScore W2023354986C203014093 @default.
- W2023354986 hasConceptScore W2023354986C2777208983 @default.
- W2023354986 hasConceptScore W2023354986C2778048844 @default.
- W2023354986 hasConceptScore W2023354986C2778621254 @default.
- W2023354986 hasConceptScore W2023354986C2779635636 @default.
- W2023354986 hasConceptScore W2023354986C2781026528 @default.
- W2023354986 hasConceptScore W2023354986C3018430615 @default.
- W2023354986 hasConceptScore W2023354986C533803919 @default.
- W2023354986 hasConceptScore W2023354986C71924100 @default.
- W2023354986 hasConceptScore W2023354986C86803240 @default.
- W2023354986 hasIssue "1" @default.