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• W2023355448 abstract "<b><i>Background:</i></b> Recent preventive strategies for patients with cognitive impairment include the identification of modifiable somatic risk factors like vitamin D deficiency. <b><i>Methods:</i></b> A systematic literature research and meta-analysis were conducted to assess the association of cognitive impairment and vitamin D deficiency. <b><i>Results:</i></b> Data from cross-sectional and longitudinal studies suggest an association between cognitive impairment and vitamin D deficiency. Meta-analysis of 5 cross-sectional and 2 longitudinal studies comprising 7,688 participants showed an increased risk of cognitive impairment in those with low vitamin D compared with normal vitamin D (OR 2.39, 95% CI 1.91–3.00; p < 0.0001). <b><i>Conclusions:</i></b> Methodological limitations of these studies comprise heterogeneity of study populations, different forms of cognitive assessment, the problem of reverse causality, different definitions of vitamin D deficiency and inconsistent control for confounders. As the value of vitamin D substitution in cognitive impairment remains doubtful, a long-time major placebo-controlled randomized trial of vitamin D supplementation in participants with mild cognitive impairment (MCI) should be started." @default.
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• W2023355448 date "2012-01-01" @default.
• W2023355448 modified "2023-10-15" @default.
• W2023355448 title "Vitamin D Deficiency, Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis" @default.
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• W2023355448 doi "https://doi.org/10.1159/000339702" @default.
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