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- W2023355522 endingPage "274" @default.
- W2023355522 startingPage "263" @default.
- W2023355522 abstract "The covalent binding of complement components C3 and C4 is critical for their activities. This reaction is made possible by the presence of an internal thioester in the native protein. Upon activation, which involves a conformational change initiated by the cleavage of a single peptide bond, the thioester becomes available to react with molecules with nucleophilic groups. This description is probably sufficient to account for the binding of the C4A isotype of human C4 to amino nucleophiles. The binding of the C4B isotype, and most likely C3, to hydroxyl nucleophiles, however, involves a histidine residue, which attacks the thioester to form an intramolecular acyl-imidazole bond. The released thiolate anion then acts as a base to catalyze the binding of hydroxyl nucleophiles, including water, to the acyl function. This mechanism allows the complement proteins to bind to the hydroxyl groups of carbohydrates found on all biological surfaces, including the components of bacterial cell walls. In addition, the fast hydrolysis of the thioester provides a means to contain this very damaging reaction to the immediate proximity of the site of activation." @default.
- W2023355522 created "2016-06-24" @default.
- W2023355522 creator A5028088223 @default.
- W2023355522 creator A5085702416 @default.
- W2023355522 date "2008-12-31" @default.
- W2023355522 modified "2023-10-10" @default.
- W2023355522 title "The internal thioester and the covalent binding properties of the complement proteins C3 and C4" @default.
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- W2023355522 doi "https://doi.org/10.1002/pro.5560060201" @default.
- W2023355522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2143658" @default.
- W2023355522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9041627" @default.