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- W2023355925 abstract "1 Selective antagonism of the cardiac β1-adrenoceptors has been studied in normal human volunteers. 2 Practolol and UK 6558 produced greater antagonism of the chronotropic and inotropic responses to i.v. isoprenaline than of the vasodilator response to either i.v. or intra-arterial isoprenaline. A third drug, M&B 17,803A, produced non-selective β-adrenoceptor blockade in 2 of 3 subjects studied. 3 Practolol, UK 6558 and M&B 17,803A, produced an attenuation of the responses to Valsalva's manoeuvre. 4 A substantial reduction in blood pressure was seen in 3 of 4 normotensive subjects given UK 6558." @default.
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- W2023355925 date "1973-09-01" @default.
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- W2023355925 title "Assessment of selective β-adrenoceptor blockade in man" @default.
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