FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023358587> ?p ?o ?g. }

• W2023358587 abstract "While human papillomavirus (HPV)-positive squamous and adenosquamous carcinomas of the oropharynx have been well characterized, HPV-associated pure adenocarcinomas are exceptionally rare. Herein we report the clinicopathologic features of one such HPV-associated adenocarcinoma of the base of tongue (BOT). A 70 year-old male presented with a 2.8 cm base of tongue mass and lymphadenopathy. Immunohistochemically, the adenocarcinoma was p63 negative and p16 positive. HPV positivity was shown by in situ hybridization. Features of salivary type tumor or metastasis from a distant primary were absent. IonTorrent™ semiconductor sequencing analysis for 739 cancer-associated mutations in 46 actionable cancer genes was performed and PIK3CA exon 9 (p.E545K) and MET exon 2 (p.E168D) mutations were identified. No PIK3CA or MET amplification was identified by fluorescence in situ hybridization. A re-review of archival HPV-positive oropharyngeal squamous cell carcinomas (n = 89, 1983-2013) showed no additional cases of adenocarcinoma. The clinical follow-up for the three previously reported cases of HPV-associated adenocarcinoma of the BOT was updated. All previously reported cases were tested and were negative for PIK3CA exon 9 and 20 and MET exon 2 mutations. These findings offer a molecular basis for potential therapeutic use of PIK3CA inhibitors in a subset of patients with HPV-associated adenocarcinoma of BOT." @default.
• W2023358587 created "2016-06-24" @default.
• W2023358587 creator A5002839107 @default.
• W2023358587 creator A5036048186 @default.
• W2023358587 creator A5040373320 @default.
• W2023358587 creator A5056955251 @default.
• W2023358587 creator A5073112024 @default.
• W2023358587 creator A5073246708 @default.
• W2023358587 creator A5073961208 @default.
• W2023358587 creator A5086760473 @default.
• W2023358587 date "2013-11-21" @default.
• W2023358587 modified "2023-09-27" @default.
• W2023358587 title "Human Papillomavirus-Associated Adenocarcinoma of the Base of Tongue: Potentially Actionable Genetic Changes" @default.
• W2023358587 cites W1972796919 @default.
• W2023358587 cites W1980000013 @default.
• W2023358587 cites W1989888272 @default.
• W2023358587 cites W1996196009 @default.
• W2023358587 cites W1999717805 @default.
• W2023358587 cites W1999946578 @default.
• W2023358587 cites W2004637409 @default.
• W2023358587 cites W2010234895 @default.
• W2023358587 cites W2021470771 @default.
• W2023358587 cites W2035420402 @default.
• W2023358587 cites W2048765718 @default.
• W2023358587 cites W2056123952 @default.
• W2023358587 cites W2058391259 @default.
• W2023358587 cites W2061195629 @default.
• W2023358587 cites W2062312459 @default.
• W2023358587 cites W2065395166 @default.
• W2023358587 cites W2079740783 @default.
• W2023358587 cites W2083461881 @default.
• W2023358587 cites W2099288345 @default.
• W2023358587 cites W2101844056 @default.
• W2023358587 cites W2117198928 @default.
• W2023358587 cites W2128164335 @default.
• W2023358587 cites W2138010881 @default.
• W2023358587 cites W2139712038 @default.
• W2023358587 cites W2143680521 @default.
• W2023358587 cites W2155598934 @default.
• W2023358587 cites W2334891695 @default.
• W2023358587 doi "https://doi.org/10.1007/s12105-013-0508-2" @default.
• W2023358587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4022938" @default.
• W2023358587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24258618" @default.
• W2023358587 hasPublicationYear "2013" @default.
• W2023358587 type Work @default.
• W2023358587 sameAs 2023358587 @default.
• W2023358587 citedByCount "10" @default.
• W2023358587 countsByYear W20233585872014 @default.
• W2023358587 countsByYear W20233585872015 @default.
• W2023358587 countsByYear W20233585872017 @default.
• W2023358587 countsByYear W20233585872019 @default.
• W2023358587 countsByYear W20233585872020 @default.
• W2023358587 countsByYear W20233585872022 @default.
• W2023358587 crossrefType "journal-article" @default.
• W2023358587 hasAuthorship W2023358587A5002839107 @default.
• W2023358587 hasAuthorship W2023358587A5036048186 @default.
• W2023358587 hasAuthorship W2023358587A5040373320 @default.
• W2023358587 hasAuthorship W2023358587A5056955251 @default.
• W2023358587 hasAuthorship W2023358587A5073112024 @default.
• W2023358587 hasAuthorship W2023358587A5073246708 @default.
• W2023358587 hasAuthorship W2023358587A5073961208 @default.
• W2023358587 hasAuthorship W2023358587A5086760473 @default.
• W2023358587 hasBestOaLocation W20233585872 @default.
• W2023358587 hasConcept C104317684 @default.
• W2023358587 hasConcept C121608353 @default.
• W2023358587 hasConcept C126322002 @default.
• W2023358587 hasConcept C142724271 @default.
• W2023358587 hasConcept C143998085 @default.
• W2023358587 hasConcept C2776512503 @default.
• W2023358587 hasConcept C2779013556 @default.
• W2023358587 hasConcept C2781182431 @default.
• W2023358587 hasConcept C36823959 @default.
• W2023358587 hasConcept C502942594 @default.
• W2023358587 hasConcept C54355233 @default.
• W2023358587 hasConcept C71924100 @default.
• W2023358587 hasConcept C86803240 @default.
• W2023358587 hasConceptScore W2023358587C104317684 @default.
• W2023358587 hasConceptScore W2023358587C121608353 @default.
• W2023358587 hasConceptScore W2023358587C126322002 @default.
• W2023358587 hasConceptScore W2023358587C142724271 @default.
• W2023358587 hasConceptScore W2023358587C143998085 @default.
• W2023358587 hasConceptScore W2023358587C2776512503 @default.
• W2023358587 hasConceptScore W2023358587C2779013556 @default.
• W2023358587 hasConceptScore W2023358587C2781182431 @default.
• W2023358587 hasConceptScore W2023358587C36823959 @default.
• W2023358587 hasConceptScore W2023358587C502942594 @default.
• W2023358587 hasConceptScore W2023358587C54355233 @default.
• W2023358587 hasConceptScore W2023358587C71924100 @default.
• W2023358587 hasConceptScore W2023358587C86803240 @default.
• W2023358587 hasLocation W20233585871 @default.
• W2023358587 hasLocation W20233585872 @default.
• W2023358587 hasLocation W20233585873 @default.
• W2023358587 hasLocation W20233585874 @default.
• W2023358587 hasOpenAccess W2023358587 @default.
• W2023358587 hasPrimaryLocation W20233585871 @default.
• W2023358587 hasRelatedWork W1412244546 @default.
• W2023358587 hasRelatedWork W162091646 @default.
• W2023358587 hasRelatedWork W1969976125 @default.
• W2023358587 hasRelatedWork W1972796919 @default.
• W2023358587 hasRelatedWork W1983019576 @default.

• next