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- W2023359817 abstract "Whether infusion of a nitric oxide (NO) synthesis inhibitor, N ω -nitro-L-arginine methyl ester (L-NAME), can modulate mural platelet deposition and neutrophil interaction with the endothelium underflow conditions was examined in ex vivo bioassay experiments. Porcine aortic media, simulating deep arterial wall injury, or porcine aortic endothelium was exposed to flowing arterial blood from L-NAME-treated pigs for 5 min at 37°C under low (424 sec -1 ) and high (3397 sec -l ) shear conditions in superfusion flow chambers. Intravenous administration of L-NAME (3 mg/kg bolus + 3 mg/kg/h perfusion) increased systolic (from 82.2 ± 2.7 to 108.5 ± 3.8 mmHg; p < 0.001). diastolic (from 47.4 ± 2.1 to 76.6 ±;3.6 mmHg; p < 0.001) and mean (from 59.0 ± 2.2 to 87.2 ± 3.6 mmHg; p < 0.001) arterial blood pressures with a slight reduction in heart rate (from 155 ± 8 to 139 ± 7 beats/min: p < 0.01). 51 Cr platelet deposition on aortic media exposed to low and high shear rates was increased, respectively, from 15.9 ± 2.9 to 20.4 ± 2.8 x 10 6 /cm 2 (p < 0.05) and from 71.4 ± 11.9 to 95.8 ± 12.5 × 10 6 /cm 2 (p < 0.02) following LNAME treatment. 111 In neutrophil adhesion to intact endothelium was also enhanced by L-NAME from 9.8 ± 2.4 to 18.3 ± 5.2 x 10 3 / cm 2 (p < 0.03) and from 12.5 ± 4.1 to 29.1 ± 8.8 x 103/cm 2 (p < 0.02) under respectively low and high shear rates. However, platelet interaction with the endothelium remained low and the endothelium maintained its thromboresistance. Administration of the specific inhibitor of NO synthesis LNAME increased arterial blood pressure and enhanced platelet interaction with the injured vessel wall and neutrophil adhesion to thromboresistant endothelium under low and high shear conditions." @default.
- W2023359817 created "2016-06-24" @default.
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- W2023359817 date "1995-02-01" @default.
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- W2023359817 title "713-5 N ω -nitro-L-arginine Methyl Ester Increases Mural Platelet Deposition and Neutrophil-endothelial Interactions Under Low and High Shear Conditions" @default.
- W2023359817 doi "https://doi.org/10.1016/0735-1097(95)91802-5" @default.
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