FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023360193> ?p ?o ?g. }

• W2023360193 endingPage "94" @default.
• W2023360193 startingPage "86" @default.
• W2023360193 abstract "Incidence of scrapie in sheep is strongly associated with PrP gene amino acid codon variants at positions 136, 154 and 171. However, there are breed differences in disease linkage and anomalous disease patterns which cannot obviously be explained by the ‘3 codon’ genotype. Mouse studies indicate that PrP protein levels can influence scrapie disease progression and this prompted us to study the sheep PrP gene promoter region in a search for novel polymorphisms which may influence gene expression and hence disease susceptibility. The incidence of three single nucleotide polymorphisms (SNP) at positions C/A-5354, T/C-5382 and C/G-5622 within the PrP gene promoter region was determined from Neuropathogenesis Unit (NPU) and New Zealand (NZ) Cheviot and UK and NZ Suffolk sheep. The SNP variants A-5354 and G-5622 created consensus sequences for STAT and SP1 transcription factors, respectively, and C-5382 was within Motif 1, one of four conserved motifs found within the promoter region of mammalian PrP genes. The occurrence of C/A-5354 and T/C-5384 SNP exhibited differential associations with the PrP open reading frame (ORF) variants linked to scrapie susceptibility. A significant imbalance in the incidence of the C-5354/AXQ haplotype was found in the NPU Cheviot flock. C-5382 was not found in Suffolk sheep of either UK or NZ origin. The G-5622 SNP was found at a lower incidence in Suffolk sheep compared with Cheviots. The range of transcription factor binding motif profiles in the PrP gene promoter may act to modulate PrP gene activity and warrants further large-scale study." @default.
• W2023360193 created "2016-06-24" @default.
• W2023360193 creator A5006806040 @default.
• W2023360193 creator A5017463196 @default.
• W2023360193 creator A5045580000 @default.
• W2023360193 creator A5050131486 @default.
• W2023360193 creator A5074647899 @default.
• W2023360193 date "2005-04-01" @default.
• W2023360193 modified "2023-09-25" @default.
• W2023360193 title "New ovine PrP gene haplotypes as a result of single nucleotide polymorphisms in the PrP gene promoter" @default.
• W2023360193 cites W1819987616 @default.
• W2023360193 cites W1821858011 @default.
• W2023360193 cites W1964712424 @default.
• W2023360193 cites W1977113963 @default.
• W2023360193 cites W1983750916 @default.
• W2023360193 cites W2011825403 @default.
• W2023360193 cites W2019032600 @default.
• W2023360193 cites W2041571977 @default.
• W2023360193 cites W2049503938 @default.
• W2023360193 cites W2050025870 @default.
• W2023360193 cites W2052317760 @default.
• W2023360193 cites W2057377540 @default.
• W2023360193 cites W2060227896 @default.
• W2023360193 cites W2072142219 @default.
• W2023360193 cites W2090844619 @default.
• W2023360193 cites W2092225663 @default.
• W2023360193 cites W2097553343 @default.
• W2023360193 cites W2103357056 @default.
• W2023360193 cites W2110015055 @default.
• W2023360193 cites W2112574135 @default.
• W2023360193 cites W2113473342 @default.
• W2023360193 cites W2119866850 @default.
• W2023360193 cites W2121859488 @default.
• W2023360193 cites W2122909430 @default.
• W2023360193 cites W2125991606 @default.
• W2023360193 cites W2128119121 @default.
• W2023360193 cites W2128667083 @default.
• W2023360193 cites W2149452024 @default.
• W2023360193 cites W2150456208 @default.
• W2023360193 cites W2166114358 @default.
• W2023360193 cites W2264024633 @default.
• W2023360193 cites W2319641678 @default.
• W2023360193 doi "https://doi.org/10.1111/j.1439-0388.2005.00520.x" @default.
• W2023360193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16130475" @default.
• W2023360193 hasPublicationYear "2005" @default.
• W2023360193 type Work @default.
• W2023360193 sameAs 2023360193 @default.
• W2023360193 citedByCount "7" @default.
• W2023360193 countsByYear W20233601932015 @default.
• W2023360193 crossrefType "journal-article" @default.
• W2023360193 hasAuthorship W2023360193A5006806040 @default.
• W2023360193 hasAuthorship W2023360193A5017463196 @default.
• W2023360193 hasAuthorship W2023360193A5045580000 @default.
• W2023360193 hasAuthorship W2023360193A5050131486 @default.
• W2023360193 hasAuthorship W2023360193A5074647899 @default.
• W2023360193 hasConcept C101762097 @default.
• W2023360193 hasConcept C104317684 @default.
• W2023360193 hasConcept C135763542 @default.
• W2023360193 hasConcept C139275648 @default.
• W2023360193 hasConcept C142724271 @default.
• W2023360193 hasConcept C150194340 @default.
• W2023360193 hasConcept C153209595 @default.
• W2023360193 hasConcept C153911025 @default.
• W2023360193 hasConcept C167625842 @default.
• W2023360193 hasConcept C197754878 @default.
• W2023360193 hasConcept C2776735649 @default.
• W2023360193 hasConcept C2779134260 @default.
• W2023360193 hasConcept C3019804061 @default.
• W2023360193 hasConcept C47289529 @default.
• W2023360193 hasConcept C54355233 @default.
• W2023360193 hasConcept C71924100 @default.
• W2023360193 hasConcept C86803240 @default.
• W2023360193 hasConceptScore W2023360193C101762097 @default.
• W2023360193 hasConceptScore W2023360193C104317684 @default.
• W2023360193 hasConceptScore W2023360193C135763542 @default.
• W2023360193 hasConceptScore W2023360193C139275648 @default.
• W2023360193 hasConceptScore W2023360193C142724271 @default.
• W2023360193 hasConceptScore W2023360193C150194340 @default.
• W2023360193 hasConceptScore W2023360193C153209595 @default.
• W2023360193 hasConceptScore W2023360193C153911025 @default.
• W2023360193 hasConceptScore W2023360193C167625842 @default.
• W2023360193 hasConceptScore W2023360193C197754878 @default.
• W2023360193 hasConceptScore W2023360193C2776735649 @default.
• W2023360193 hasConceptScore W2023360193C2779134260 @default.
• W2023360193 hasConceptScore W2023360193C3019804061 @default.
• W2023360193 hasConceptScore W2023360193C47289529 @default.
• W2023360193 hasConceptScore W2023360193C54355233 @default.
• W2023360193 hasConceptScore W2023360193C71924100 @default.
• W2023360193 hasConceptScore W2023360193C86803240 @default.
• W2023360193 hasIssue "2" @default.
• W2023360193 hasLocation W20233601931 @default.
• W2023360193 hasLocation W20233601932 @default.
• W2023360193 hasOpenAccess W2023360193 @default.
• W2023360193 hasPrimaryLocation W20233601931 @default.
• W2023360193 hasRelatedWork W1901150897 @default.
• W2023360193 hasRelatedWork W1966708416 @default.
• W2023360193 hasRelatedWork W1991789174 @default.
• W2023360193 hasRelatedWork W2023360193 @default.

• next