Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023360252> ?p ?o ?g. }
- W2023360252 endingPage "1136" @default.
- W2023360252 startingPage "1125" @default.
- W2023360252 abstract "Although isoforms of Ca2+/calmodulin-dependent protein kinase II (CaMKII) have been implicated in the regulation of gene expression in cultured cells, this issue has yet to be addressed in vivo. We report that the overexpression of calmodulin in ventricular myocytes of transgenic mice results in an increase in the Ca2+/calmodulin-independent activity of endogenous CaMKII. The calmodulin transgene is regulated by a 500-bp fragment of the atrial natriuretic factor (ANF) gene promoter which, based on cell transfection studies, is itself known to be regulated by CaMKII. The increased autonomous activity of CaMKII maintains the activity of the transgene and establishes a positive feed-forward loop, which also extends the temporal expression of the endogenous ANF promoter in ventricular myocytes. Both the increased activity of CaMKII and transcriptional activation of ANF are highly selective responses to the chronic overexpression of calmodulin. These results indicate that CaMKII can regulate gene expression in vivo and suggest that this enzyme may represent the Ca2+-dependent target responsible for reactivation of the ANF gene during ventricular hypertrophy." @default.
- W2023360252 created "2016-06-24" @default.
- W2023360252 creator A5010771786 @default.
- W2023360252 creator A5085156788 @default.
- W2023360252 date "2000-08-01" @default.
- W2023360252 modified "2023-10-16" @default.
- W2023360252 title "Chronic Elevation of Calmodulin in the Ventricles of Transgenic Mice Increases the Autonomous Activity of Calmodulin-Dependent Protein Kinase II, Which Regulates Atrial Natriuretic Factor Gene Expression" @default.
- W2023360252 cites W118450862 @default.
- W2023360252 cites W1533807820 @default.
- W2023360252 cites W1535121904 @default.
- W2023360252 cites W1567466567 @default.
- W2023360252 cites W1576265914 @default.
- W2023360252 cites W1602728552 @default.
- W2023360252 cites W1603731520 @default.
- W2023360252 cites W1769270835 @default.
- W2023360252 cites W1857652952 @default.
- W2023360252 cites W1963840916 @default.
- W2023360252 cites W1967046995 @default.
- W2023360252 cites W1977596244 @default.
- W2023360252 cites W1983207595 @default.
- W2023360252 cites W1987421901 @default.
- W2023360252 cites W1988528174 @default.
- W2023360252 cites W1997261857 @default.
- W2023360252 cites W1998678953 @default.
- W2023360252 cites W2000831803 @default.
- W2023360252 cites W2002524744 @default.
- W2023360252 cites W2004735731 @default.
- W2023360252 cites W200979646 @default.
- W2023360252 cites W2014371208 @default.
- W2023360252 cites W2015356283 @default.
- W2023360252 cites W2024257303 @default.
- W2023360252 cites W2026315931 @default.
- W2023360252 cites W2029964088 @default.
- W2023360252 cites W2034856894 @default.
- W2023360252 cites W2035391953 @default.
- W2023360252 cites W2052248858 @default.
- W2023360252 cites W2055480062 @default.
- W2023360252 cites W2061405398 @default.
- W2023360252 cites W2067244759 @default.
- W2023360252 cites W2067529350 @default.
- W2023360252 cites W2072087613 @default.
- W2023360252 cites W2074593407 @default.
- W2023360252 cites W2080999736 @default.
- W2023360252 cites W2081418915 @default.
- W2023360252 cites W2081704409 @default.
- W2023360252 cites W2082201094 @default.
- W2023360252 cites W2082547186 @default.
- W2023360252 cites W2083087488 @default.
- W2023360252 cites W2086482086 @default.
- W2023360252 cites W2089605114 @default.
- W2023360252 cites W2089697406 @default.
- W2023360252 cites W2091163358 @default.
- W2023360252 cites W2113934901 @default.
- W2023360252 cites W2117668393 @default.
- W2023360252 cites W2124285310 @default.
- W2023360252 cites W2135011583 @default.
- W2023360252 cites W2140707292 @default.
- W2023360252 cites W2144630422 @default.
- W2023360252 cites W2152150574 @default.
- W2023360252 cites W2156433522 @default.
- W2023360252 cites W2158800467 @default.
- W2023360252 cites W2160013321 @default.
- W2023360252 cites W2164949284 @default.
- W2023360252 cites W2206467126 @default.
- W2023360252 cites W2318916020 @default.
- W2023360252 cites W320970327 @default.
- W2023360252 cites W42796100 @default.
- W2023360252 doi "https://doi.org/10.1210/mend.14.8.0496" @default.
- W2023360252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10935538" @default.
- W2023360252 hasPublicationYear "2000" @default.
- W2023360252 type Work @default.
- W2023360252 sameAs 2023360252 @default.
- W2023360252 citedByCount "41" @default.
- W2023360252 countsByYear W20233602522012 @default.
- W2023360252 countsByYear W20233602522015 @default.
- W2023360252 countsByYear W20233602522017 @default.
- W2023360252 countsByYear W20233602522018 @default.
- W2023360252 countsByYear W20233602522019 @default.
- W2023360252 crossrefType "journal-article" @default.
- W2023360252 hasAuthorship W2023360252A5010771786 @default.
- W2023360252 hasAuthorship W2023360252A5085156788 @default.
- W2023360252 hasBestOaLocation W20233602521 @default.
- W2023360252 hasConcept C102230213 @default.
- W2023360252 hasConcept C104317684 @default.
- W2023360252 hasConcept C134018914 @default.
- W2023360252 hasConcept C141035611 @default.
- W2023360252 hasConcept C150194340 @default.
- W2023360252 hasConcept C153911025 @default.
- W2023360252 hasConcept C165864922 @default.
- W2023360252 hasConcept C16613235 @default.
- W2023360252 hasConcept C181199279 @default.
- W2023360252 hasConcept C184235292 @default.
- W2023360252 hasConcept C29688787 @default.
- W2023360252 hasConcept C53345823 @default.
- W2023360252 hasConcept C55493867 @default.
- W2023360252 hasConcept C86803240 @default.
- W2023360252 hasConcept C95444343 @default.
- W2023360252 hasConcept C97029542 @default.