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- W2023360598 abstract "The inactivating and mutagenic action of high-energy radiations with different ionizing capacities (γ-rays, protons, α-particles and accelerated ions of 12C and 20Ne) was studied by using coliphages λ11 and sd as subjects. In particular the role of irradiation conditions (broth suspension, pure buffer, dry samples) and of the host functions recA, exrA and polA was investigated. The dose-response curve of induced mutagenesis was studied by measuring the yield of vir mutants in λ11 and plaque mutants in sd. The following results were obtained. (1) The inactivation kinetics of phages under the action of γ-rays and protons was first order to a survival of 10−7. Heavy ions also showed exponential inactivation kinetics to a survival of 10−4. At higher doses of 20Ne ion bombardment some deviation from one-hit kinetics was observed. For dry samples of phages the dimensions of targets for all types of radiation were approximately proportional to the molecular weights of phage DNA's. For densely ionizing radiation (heavy ions) the inactivating action was 3–5 times weaker than for γ-rays and protons. (2) Mutagenesis was observed for all types of radiation, but heavy ions were 1.5–2 times less efficient than γ-rays. For both phages studied the dose-response curve of mutagenesis was non-linear. The dependence on the dose was near to parabolic for λ11. For sd a plateau or maximum of mutagenesis was observed for the relative number of mutants at a survival of about 10−4. (3) Host-cell functions recA and exrA were practically indifferent for survival of γ-irradiated phage λ11, but indispensable for mutagenesis. Mutation recA13 abolished induced vir mutations totally and exrA− reduced them significantly. The absence of the function polA had a considerable influence on phage survival, but no effect on vir mutation yield (if compared at the same survival level). (4) In conditions of indirect action of γ-rays no vir mutations were induced. This is regarded as evidence that the single-strand breaks formed under indirect action conditions cannot serve as pre-mutational damage in DNA." @default.
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- W2023360598 date "1975-07-01" @default.
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- W2023360598 title "Study of genetic effects of high energy radiations with different ionizing capacities on extracellular phages" @default.
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- W2023360598 doi "https://doi.org/10.1016/0027-5107(75)90017-2" @default.
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