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- W2023361107 abstract "Introduction: The effect of antidepressant therapy on the quality of life of older medically ill depressed individuals has not been well studied. In this report the authors describe their experience and preliminary results from an ongoing study evaluating the relationship between major depression and quality of life in elderly subjects with serious medical illnesses. Methods: 14 subjects, 61–80 years, mean age=70 ± 6 years, 8 women, were recruited after written informed consent. All met DSM-IV criteria for major depression and received the SF-36, 17 item Ham-D, and the Cumulative Illness Rating Scale (CIRS-G) before and during treatment with bupropion SR. The authors report the distribution and psychometric properties of the rating instruments as well as relationships between baseline ratings of depression, medical burden, and quality of life. Results: The mean±SD for Ham-D was 18.6±4 and CIRS-G was 12±6 (6–31). Mean scores for the SF36 items were: physical functioning 46±31, role-physical 23±33, bodily pain 58±31, general health 46±25, vitality 26±21, social functioning 39±27, and role-emotional 31±38, mental health 43±18, health transition 43±25. A high correlation (r=0.70) was observed between somatic symptoms and work/activity level. The CIRS-G “vascular” item correlated with the Ham-D (r=0.40) weakly. Among SF-36 domains, physical functioning and general health were most closely correlated (r=0.88). Conclusions: These and other pilot results of the authors' ongoing study are discussed in relation to the impact of depression on quality of life in medically ill geriatric patients. P35" @default.
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- W2023361107 date "1999-09-01" @default.
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- W2023361107 title "DEPRESSION, MEDICAL ILLNESS, AND QUALITY OF LIFE IN OLDER INDIVIDUALS: PRELIMINARY FINDINGS" @default.
- W2023361107 doi "https://doi.org/10.1097/00019442-199911001-00116" @default.
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