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• W2023361163 startingPage "S62" @default.
• W2023361163 abstract "The intestinal epithelial cell (IEC) barrier plays an important role in maintaining mucosal immune homeostasis. Dysregulated IEC barrier function appears to trigger and perpetuate inflammation in inflammatory bowel diseases (IBD). Novel risk variants in the Toll-like receptor 2 (TLR2) gene have previously been associated with a more severe disease phenotype in a subgroup of IBD patients. Recent studies have provided important insights of the commensal and host defense mechanisms to maintain functional barrier integrity of the intestinal epithelium through TLR2. Deficient TLR2 signaling may imbalance commensal-dependent intestinal epithelial barrier defense, facilitating mucosal injury and leading to increased susceptibility of colitis. Treatment with a synthetic TLR2 ligand significantly suppresses mucosal inflammation by efficiently protecting tight junction-associated integrity of the intestinal epithelium in vivo. These beneficial effects may be supplemented by TLR2-induced anti-inflammatory immune responses (such as interleukin-10 production) in lamina propria mononuclear cells. Thus, cell-specific TLR2 targeting may offer a novel therapeutic approach to human IBD therapy by protecting IEC barrier function." @default.
• W2023361163 created "2016-06-24" @default.
• W2023361163 creator A5011843830 @default.
• W2023361163 date "2008-11-01" @default.
• W2023361163 modified "2023-10-17" @default.
• W2023361163 title "Barrier-protective function of intestinal epithelial Toll-like receptor 2" @default.
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• W2023361163 doi "https://doi.org/10.1038/mi.2008.47" @default.
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