Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023361410> ?p ?o ?g. }
- W2023361410 endingPage "176" @default.
- W2023361410 startingPage "167" @default.
- W2023361410 abstract "The lack of dystrophin in mdx mice and in Duchenne muscular dystrophy causes sarcolemmal breakdown and increased calcium influx followed by myonecrosis. We examined whether the calcium channel blockers diltiazem and verapamil protect dystrophic muscles from degeneration. Mdx mice received daily intraperitoneal injections of diltiazem or verapamil for 18 days, followed by removal of the sternomastoid, diaphragm, tibialis anterior, and cardiac muscles. Control mdx mice were injected with saline. Both drugs significantly decreased blood creatine kinase levels. Total calcium content was significantly higher in mdx muscles than in control C57Bl/10. Verapamil and diltiazem reduced total calcium content only in diaphragm and cardiac muscle. Histological analysis showed that diltiazem significantly attenuated myonecrosis in diaphragm. Immunoblots showed a significant increase of calsequestrin and beta-dystroglycan levels in some diltiazem- and verapamil-treated muscles. Possible interactions of these drugs with the sarcoplasmic reticulum and sarcolemma may also contribute to the improvement of the dystrophic phenotype." @default.
- W2023361410 created "2016-06-24" @default.
- W2023361410 creator A5064291029 @default.
- W2023361410 creator A5074546515 @default.
- W2023361410 creator A5076171496 @default.
- W2023361410 creator A5079973717 @default.
- W2023361410 creator A5088488609 @default.
- W2023361410 date "2009-02-01" @default.
- W2023361410 modified "2023-09-30" @default.
- W2023361410 title "Diltiazem and verapamil protect dystrophin-deficient muscle fibers of<i>MDX</i>mice from degeneration: A potential role in calcium buffering and sarcolemmal stability" @default.
- W2023361410 cites W1601005193 @default.
- W2023361410 cites W1963532383 @default.
- W2023361410 cites W1964156849 @default.
- W2023361410 cites W1970848490 @default.
- W2023361410 cites W1981342198 @default.
- W2023361410 cites W1981909460 @default.
- W2023361410 cites W1985396526 @default.
- W2023361410 cites W2000160674 @default.
- W2023361410 cites W2000855370 @default.
- W2023361410 cites W2008936792 @default.
- W2023361410 cites W2008980136 @default.
- W2023361410 cites W2010762668 @default.
- W2023361410 cites W2020180085 @default.
- W2023361410 cites W2021749053 @default.
- W2023361410 cites W2027829434 @default.
- W2023361410 cites W2029391788 @default.
- W2023361410 cites W2031015155 @default.
- W2023361410 cites W2034790803 @default.
- W2023361410 cites W2035079270 @default.
- W2023361410 cites W2038013299 @default.
- W2023361410 cites W2039306818 @default.
- W2023361410 cites W2047015778 @default.
- W2023361410 cites W2051471541 @default.
- W2023361410 cites W2055224057 @default.
- W2023361410 cites W2058140775 @default.
- W2023361410 cites W2059255522 @default.
- W2023361410 cites W2062178098 @default.
- W2023361410 cites W2062628051 @default.
- W2023361410 cites W2063893684 @default.
- W2023361410 cites W2065255554 @default.
- W2023361410 cites W2066237736 @default.
- W2023361410 cites W2067146747 @default.
- W2023361410 cites W2070936696 @default.
- W2023361410 cites W2072088562 @default.
- W2023361410 cites W2072531353 @default.
- W2023361410 cites W2081902497 @default.
- W2023361410 cites W2083068052 @default.
- W2023361410 cites W2093907840 @default.
- W2023361410 cites W2095157830 @default.
- W2023361410 cites W2098263284 @default.
- W2023361410 cites W2101040034 @default.
- W2023361410 cites W2111234060 @default.
- W2023361410 cites W2115087559 @default.
- W2023361410 cites W2128270335 @default.
- W2023361410 cites W2136293998 @default.
- W2023361410 cites W2140132082 @default.
- W2023361410 cites W2155823358 @default.
- W2023361410 cites W2156746326 @default.
- W2023361410 cites W2168984459 @default.
- W2023361410 doi "https://doi.org/10.1002/mus.21188" @default.
- W2023361410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19145649" @default.
- W2023361410 hasPublicationYear "2009" @default.
- W2023361410 type Work @default.
- W2023361410 sameAs 2023361410 @default.
- W2023361410 citedByCount "29" @default.
- W2023361410 countsByYear W20233614102012 @default.
- W2023361410 countsByYear W20233614102013 @default.
- W2023361410 countsByYear W20233614102014 @default.
- W2023361410 countsByYear W20233614102015 @default.
- W2023361410 countsByYear W20233614102016 @default.
- W2023361410 countsByYear W20233614102017 @default.
- W2023361410 countsByYear W20233614102018 @default.
- W2023361410 countsByYear W20233614102019 @default.
- W2023361410 countsByYear W20233614102020 @default.
- W2023361410 countsByYear W20233614102021 @default.
- W2023361410 countsByYear W20233614102023 @default.
- W2023361410 crossrefType "journal-article" @default.
- W2023361410 hasAuthorship W2023361410A5064291029 @default.
- W2023361410 hasAuthorship W2023361410A5074546515 @default.
- W2023361410 hasAuthorship W2023361410A5076171496 @default.
- W2023361410 hasAuthorship W2023361410A5079973717 @default.
- W2023361410 hasAuthorship W2023361410A5088488609 @default.
- W2023361410 hasConcept C126322002 @default.
- W2023361410 hasConcept C134018914 @default.
- W2023361410 hasConcept C139966638 @default.
- W2023361410 hasConcept C185592680 @default.
- W2023361410 hasConcept C199096232 @default.
- W2023361410 hasConcept C2776741139 @default.
- W2023361410 hasConcept C2777022698 @default.
- W2023361410 hasConcept C2778750056 @default.
- W2023361410 hasConcept C2778943923 @default.
- W2023361410 hasConcept C2779959927 @default.
- W2023361410 hasConcept C2780394045 @default.
- W2023361410 hasConcept C36880943 @default.
- W2023361410 hasConcept C519063684 @default.
- W2023361410 hasConcept C71924100 @default.
- W2023361410 hasConceptScore W2023361410C126322002 @default.
- W2023361410 hasConceptScore W2023361410C134018914 @default.