FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023361486> ?p ?o ?g. }

• W2023361486 endingPage "176" @default.
• W2023361486 startingPage "169" @default.
• W2023361486 abstract "High expression of Cyr61, an extracellular cysteine-rich heparin-binding protein, has been associated with a malignant cell phenotype and poor outcome in prostate cancers. Although Cyr61 was found by us to be overproduced in androgen-independent PC-3 cells treated with N-acetylcysteine (NAC), its significance is still unclear. We therefore aimed to determine how and why Cyr61 protein is overexpressed in NAC-treated cells. Here, we found that Cyr61 protein level markedly increased in cells treated with NAC at high cell seeding density. Silencing of Cyr61 by siRNA induced enhanced activity of caspase-3/7, upregulation of the proapototic Bok, BimL and BimS, cleavage of apoptosis hallmarkers such as Bax, PARP and caspase-3, and downregulation of antiapoptotic Bcl2, Bcl-xL and Mcl-1 proteins. NAC treatment caused a reduction of extracellular medium pH to acidic and an increase in Akt phosphorylation, after which the replacement with NAC-free medium returned them to control levels within 24 h. Acid stimulation increased the levels of Cyr61 and p-Akt proteins, whereas it suppressed the induction of proapoptotic and antiapoptotic proteins. Overall, our data indicate that PC-3 cells overproduce Cyr61 protein via activation of the PI3K/Akt signaling as a part of the survival mechanisms under the conditions causing extracellular acidity and further cytotoxicity." @default.
• W2023361486 created "2016-06-24" @default.
• W2023361486 creator A5004621751 @default.
• W2023361486 creator A5022162451 @default.
• W2023361486 creator A5066822946 @default.
• W2023361486 date "2013-08-01" @default.
• W2023361486 modified "2023-10-18" @default.
• W2023361486 title "Production of Cyr61 protein is modulated by extracellular acidification and PI3K/Akt signaling in prostate carcinoma PC-3 cells" @default.
• W2023361486 cites W1567058039 @default.
• W2023361486 cites W1593707784 @default.
• W2023361486 cites W1793987231 @default.
• W2023361486 cites W1966754723 @default.
• W2023361486 cites W1974187464 @default.
• W2023361486 cites W1992500766 @default.
• W2023361486 cites W2007329651 @default.
• W2023361486 cites W2007827117 @default.
• W2023361486 cites W2013603554 @default.
• W2023361486 cites W2016133409 @default.
• W2023361486 cites W2019872821 @default.
• W2023361486 cites W2020773324 @default.
• W2023361486 cites W2032912914 @default.
• W2023361486 cites W2037730083 @default.
• W2023361486 cites W2047781799 @default.
• W2023361486 cites W2049976919 @default.
• W2023361486 cites W2053865773 @default.
• W2023361486 cites W2060184827 @default.
• W2023361486 cites W2078690146 @default.
• W2023361486 cites W2083456979 @default.
• W2023361486 cites W2086354663 @default.
• W2023361486 cites W2092361248 @default.
• W2023361486 cites W2093334711 @default.
• W2023361486 cites W2100093802 @default.
• W2023361486 cites W2114752142 @default.
• W2023361486 cites W2120942023 @default.
• W2023361486 cites W2134286908 @default.
• W2023361486 cites W2135944976 @default.
• W2023361486 cites W2138768698 @default.
• W2023361486 cites W2143433681 @default.
• W2023361486 cites W2146133427 @default.
• W2023361486 cites W2148051205 @default.
• W2023361486 cites W2152373201 @default.
• W2023361486 cites W2154922703 @default.
• W2023361486 cites W2157600583 @default.
• W2023361486 cites W2161702414 @default.
• W2023361486 cites W2164414468 @default.
• W2023361486 cites W2180781245 @default.
• W2023361486 cites W2316875490 @default.
• W2023361486 doi "https://doi.org/10.1016/j.fct.2013.04.035" @default.
• W2023361486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23623839" @default.
• W2023361486 hasPublicationYear "2013" @default.
• W2023361486 type Work @default.
• W2023361486 sameAs 2023361486 @default.
• W2023361486 citedByCount "12" @default.
• W2023361486 countsByYear W20233614862013 @default.
• W2023361486 countsByYear W20233614862014 @default.
• W2023361486 countsByYear W20233614862015 @default.
• W2023361486 countsByYear W20233614862016 @default.
• W2023361486 countsByYear W20233614862017 @default.
• W2023361486 countsByYear W20233614862018 @default.
• W2023361486 countsByYear W20233614862019 @default.
• W2023361486 countsByYear W20233614862023 @default.
• W2023361486 crossrefType "journal-article" @default.
• W2023361486 hasAuthorship W2023361486A5004621751 @default.
• W2023361486 hasAuthorship W2023361486A5022162451 @default.
• W2023361486 hasAuthorship W2023361486A5066822946 @default.
• W2023361486 hasConcept C104317684 @default.
• W2023361486 hasConcept C127561419 @default.
• W2023361486 hasConcept C170493617 @default.
• W2023361486 hasConcept C185592680 @default.
• W2023361486 hasConcept C190283241 @default.
• W2023361486 hasConcept C2775960820 @default.
• W2023361486 hasConcept C2778753947 @default.
• W2023361486 hasConcept C2780631158 @default.
• W2023361486 hasConcept C28406088 @default.
• W2023361486 hasConcept C502942594 @default.
• W2023361486 hasConcept C55493867 @default.
• W2023361486 hasConcept C75217442 @default.
• W2023361486 hasConcept C86554907 @default.
• W2023361486 hasConcept C86803240 @default.
• W2023361486 hasConcept C95444343 @default.
• W2023361486 hasConceptScore W2023361486C104317684 @default.
• W2023361486 hasConceptScore W2023361486C127561419 @default.
• W2023361486 hasConceptScore W2023361486C170493617 @default.
• W2023361486 hasConceptScore W2023361486C185592680 @default.
• W2023361486 hasConceptScore W2023361486C190283241 @default.
• W2023361486 hasConceptScore W2023361486C2775960820 @default.
• W2023361486 hasConceptScore W2023361486C2778753947 @default.
• W2023361486 hasConceptScore W2023361486C2780631158 @default.
• W2023361486 hasConceptScore W2023361486C28406088 @default.
• W2023361486 hasConceptScore W2023361486C502942594 @default.
• W2023361486 hasConceptScore W2023361486C55493867 @default.
• W2023361486 hasConceptScore W2023361486C75217442 @default.
• W2023361486 hasConceptScore W2023361486C86554907 @default.
• W2023361486 hasConceptScore W2023361486C86803240 @default.
• W2023361486 hasConceptScore W2023361486C95444343 @default.
• W2023361486 hasLocation W20233614861 @default.
• W2023361486 hasLocation W20233614862 @default.
• W2023361486 hasOpenAccess W2023361486 @default.

• next