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• W2023361556 abstract "Ultrasound (US) is used widely in the context of breast cancer. While it is advantageous for a number of reasons, it has low specificity and requires the use of a contrast agent. Its use as a standalone diagnostic and real-time imaging modality could be achieved by development of a tumor-targeted ultrasound contrast agent (UCA); functionalizing the UCA with a tumor-targeting agent would also allow the targeted administration of anti-cancer drugs at the tumor site. In this article, clinical US techniques are used to show that mesoporous silica nanoparticles (MSNs), functionalized with the monoclonal antibody Herceptin®, can be used as an effective UCA by increasing US image contrast. Furthermore, in vitro assays show the successful localization and binding of the MSN-Herceptin conjugate to HER2+ cancer cells, resulting in tumor-specific cytotoxicity. These results demonstrate the potential of MSNs as a stable, biocompatible, and effective therapeutic and diagnostic (“theranostic”) agent for US-based breast cancer imaging, diagnosis, and treatment." @default.
• W2023361556 created "2016-06-24" @default.
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• W2023361556 date "2014-04-01" @default.
• W2023361556 modified "2023-10-06" @default.
• W2023361556 title "Mesoporous silica nanoparticles as a breast-cancer targeting ultrasound contrast agent" @default.
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• W2023361556 doi "https://doi.org/10.1016/j.colsurfb.2013.10.038" @default.
• W2023361556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4687408" @default.
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