FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023362285> ?p ?o ?g. }

• W2023362285 endingPage "732" @default.
• W2023362285 startingPage "726" @default.
• W2023362285 abstract "Nuclear expression of the Y-box-binding protein-1 (YB-1) has been reported to regulate the expression of both P-glycoprotein (P-gp) and major vault protein (MVP), and to regulate proliferative activities in human malignancies. Based on morphology and molecular biology, rhabdomyosarcoma (RMS) can be divided into two major types: embryonal type and the more aggressive alveolar type. Thirty-five cases of embryonal RMS (ERMS) and 28 cases of alveolar RMS (ARMS) were examined immunohistochemically for the nuclear expression of YB-1 and the intrinsic expression of P-gp, multidrug resistance (MDR)-associated protein (MRP) 1, 2, and 3, breast-cancer resistant protein (BCRP) and MVP, and the findings were compared with proliferative activities as evaluated by the MIB-1-labeling index (LI). Moreover, mRNA levels of these MDR-related molecules were assessed using a quantitative reverse transcriptase-PCR method in 18 concordant frozen materials. P-gp expression was more frequently observed ARMS, compared with ERMS (P = 0.0332), whereas immunoreactivity for BCRP was more frequently recognized in ERMS (P = 0.0184). Nuclear expression of YB-1 protein was correlated with P-gp (P = 0.0359) and MVP (P = 0.0044) expression, and a higher MIB-1-labeling index (P = 0.0244) in ERMS, however, in ARMS no such relationships were observed. These immunohistochemical results indicate that different expression profiles of MDR-related molecules and their correlation with YB-1 nuclear expression support the concept that ERMS and ARMS are molecular biologically distinct neoplasms. Apart from ERMS, frequent P-gp expression in ARMS may be independent from YB-1 regulation. However, YB-1 may be a candidate for a molecular target in rhabdomyosarcoma therapy, especially in ERMS." @default.
• W2023362285 created "2016-06-24" @default.
• W2023362285 creator A5008359331 @default.
• W2023362285 creator A5011966088 @default.
• W2023362285 creator A5012193751 @default.
• W2023362285 creator A5025082835 @default.
• W2023362285 creator A5041401659 @default.
• W2023362285 creator A5043041975 @default.
• W2023362285 creator A5049884976 @default.
• W2023362285 creator A5053242194 @default.
• W2023362285 creator A5082131946 @default.
• W2023362285 creator A5085314163 @default.
• W2023362285 date "2008-03-28" @default.
• W2023362285 modified "2023-10-15" @default.
• W2023362285 title "Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcoma" @default.
• W2023362285 cites W1579283411 @default.
• W2023362285 cites W1926287352 @default.
• W2023362285 cites W1965587103 @default.
• W2023362285 cites W1968931590 @default.
• W2023362285 cites W1970218983 @default.
• W2023362285 cites W1972062962 @default.
• W2023362285 cites W1989752636 @default.
• W2023362285 cites W2005550277 @default.
• W2023362285 cites W2026104663 @default.
• W2023362285 cites W2040408668 @default.
• W2023362285 cites W2057405658 @default.
• W2023362285 cites W2060512760 @default.
• W2023362285 cites W2065072706 @default.
• W2023362285 cites W2076174476 @default.
• W2023362285 cites W2083613146 @default.
• W2023362285 cites W2088245792 @default.
• W2023362285 cites W2121871121 @default.
• W2023362285 cites W2125955976 @default.
• W2023362285 cites W2140847482 @default.
• W2023362285 cites W2158139146 @default.
• W2023362285 cites W2160417212 @default.
• W2023362285 cites W2175015884 @default.
• W2023362285 cites W2248842252 @default.
• W2023362285 cites W2267290488 @default.
• W2023362285 cites W2317025328 @default.
• W2023362285 cites W2329552021 @default.
• W2023362285 cites W43589343 @default.
• W2023362285 doi "https://doi.org/10.1111/j.1349-7006.2008.00748.x" @default.
• W2023362285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18377424" @default.
• W2023362285 hasPublicationYear "2008" @default.
• W2023362285 type Work @default.
• W2023362285 sameAs 2023362285 @default.
• W2023362285 citedByCount "20" @default.
• W2023362285 countsByYear W20233622852012 @default.
• W2023362285 countsByYear W20233622852013 @default.
• W2023362285 countsByYear W20233622852014 @default.
• W2023362285 countsByYear W20233622852015 @default.
• W2023362285 countsByYear W20233622852016 @default.
• W2023362285 countsByYear W20233622852017 @default.
• W2023362285 countsByYear W20233622852020 @default.
• W2023362285 countsByYear W20233622852021 @default.
• W2023362285 countsByYear W20233622852022 @default.
• W2023362285 crossrefType "journal-article" @default.
• W2023362285 hasAuthorship W2023362285A5008359331 @default.
• W2023362285 hasAuthorship W2023362285A5011966088 @default.
• W2023362285 hasAuthorship W2023362285A5012193751 @default.
• W2023362285 hasAuthorship W2023362285A5025082835 @default.
• W2023362285 hasAuthorship W2023362285A5041401659 @default.
• W2023362285 hasAuthorship W2023362285A5043041975 @default.
• W2023362285 hasAuthorship W2023362285A5049884976 @default.
• W2023362285 hasAuthorship W2023362285A5053242194 @default.
• W2023362285 hasAuthorship W2023362285A5082131946 @default.
• W2023362285 hasAuthorship W2023362285A5085314163 @default.
• W2023362285 hasBestOaLocation W20233622851 @default.
• W2023362285 hasConcept C104317684 @default.
• W2023362285 hasConcept C105580179 @default.
• W2023362285 hasConcept C114851261 @default.
• W2023362285 hasConcept C133936738 @default.
• W2023362285 hasConcept C142724271 @default.
• W2023362285 hasConcept C153911025 @default.
• W2023362285 hasConcept C204232928 @default.
• W2023362285 hasConcept C2776522094 @default.
• W2023362285 hasConcept C2777176876 @default.
• W2023362285 hasConcept C2778256501 @default.
• W2023362285 hasConcept C2778707650 @default.
• W2023362285 hasConcept C2780844630 @default.
• W2023362285 hasConcept C502942594 @default.
• W2023362285 hasConcept C54355233 @default.
• W2023362285 hasConcept C71924100 @default.
• W2023362285 hasConcept C86803240 @default.
• W2023362285 hasConceptScore W2023362285C104317684 @default.
• W2023362285 hasConceptScore W2023362285C105580179 @default.
• W2023362285 hasConceptScore W2023362285C114851261 @default.
• W2023362285 hasConceptScore W2023362285C133936738 @default.
• W2023362285 hasConceptScore W2023362285C142724271 @default.
• W2023362285 hasConceptScore W2023362285C153911025 @default.
• W2023362285 hasConceptScore W2023362285C204232928 @default.
• W2023362285 hasConceptScore W2023362285C2776522094 @default.
• W2023362285 hasConceptScore W2023362285C2777176876 @default.
• W2023362285 hasConceptScore W2023362285C2778256501 @default.
• W2023362285 hasConceptScore W2023362285C2778707650 @default.
• W2023362285 hasConceptScore W2023362285C2780844630 @default.
• W2023362285 hasConceptScore W2023362285C502942594 @default.

• next