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- W2023362484 abstract "Hepatic artery infusion of 5-fluorouracil via transbrachial artery catheter by repeated acute monthly courses has been used in 101 patients. Objective regressions were seen in 39 of 68 patients (59%) with gastrointestinal malignancies; however, only rare regressions were observed in 41 neoplasms of other primary sites. Twenty patients were treated adequately by prolonged continuous infusion of 5-fluoro-2′-deoxyuridine. Five of these patients obtained objective regressions. This was not a randomized comparative study of the two methods but comprised two separate studies. The acute intermittent program appeared superior to prolonged chronic infusion; however, with the latter method, he-matopoietic toxicity was less severe. The use of hepatic artery catheters positioned via the brachial artery has been a practical and effective method of pursuing this form of therapy with the major significant complication, irreversible ischemic changes of the fingers and hand, occurring in only two patients." @default.
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- W2023362484 date "1967-11-01" @default.
- W2023362484 modified "2023-10-18" @default.
- W2023362484 title "Infusion of fluorinated pyrimidines into hepatic artery for treatment of metastatic carcinoma of liver" @default.
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- W2023362484 doi "https://doi.org/10.1002/1097-0142(196711)20:11<1886::aid-cncr2820201114>3.0.co;2-s" @default.
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