FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023362805> ?p ?o ?g. }

• W2023362805 endingPage "16297" @default.
• W2023362805 startingPage "16289" @default.
• W2023362805 abstract "We report the resonance Raman characterization of the heme domain of rat lung soluble guanylate cyclase (sGC) expressed in Escherichia coli. Like heterodimeric sGC isolated from bovine lung, the sGC heme domain [β1(1−385)] and its heme ligand mutant H105G(Im) contain a stoichiometric amount of heme, which is five-coordinate, high-spin ferrous in both β1(1−385) and chemically reduced H105G(Im). In the presence of NO, both β1(1−385) and H105G(Im) form a five-coordinate nitrosyl heme complex with a ν(Fe−NO) value of 525 cm-1 and a ν(NO) value of 1676 cm-1. For the first time, the Fe−N−O bending mode near 400 cm-1 has been identified in a five-coordinate nitrosyl heme complex. Both β1(1−385) and H105G(Im) form a six-coordinate, low-spin complex with CO. We find evidence for two binding conformations of the Fe−CO unit. The conformation that is more prevalent in β1(1−385) has a ν(Fe−CO) value of 478 cm-1 and a δ(Fe−C−O) value of 567 cm-1, whereas the dominant conformation in H105G(Im) is characterized by a ν(Fe−CO) value of 495 cm-1 and a δ(Fe−C−O) value of 572 cm-1. We propose that in the dominant conformation of H105G(Im)−CO the Fe−CO unit is hydrogen bonded to a distal residue, while this is not the case in β1(1−385). Reexamination of sGC isolated from bovine lung tissue indicates that it also has two binding conformations for CO; the more populated form is not hydrogen-bonded. We propose that the absence of hydrogen-bond formation between a distal residue and exogenous ligands is physiologically relevant in lowering the oxygen affinity of heterodimeric sGC and, therefore, stabilizing the ferrous, active form of the enzyme under aerobic conditions." @default.
• W2023362805 created "2016-06-24" @default.
• W2023362805 creator A5024547909 @default.
• W2023362805 creator A5028940854 @default.
• W2023362805 creator A5039561796 @default.
• W2023362805 creator A5083741791 @default.
• W2023362805 date "1998-10-28" @default.
• W2023362805 modified "2023-10-17" @default.
• W2023362805 title "Resonance Raman Characterization of the Heme Domain of Soluble Guanylate Cyclase" @default.
• W2023362805 cites W1494243136 @default.
• W2023362805 cites W1497834055 @default.
• W2023362805 cites W1509418264 @default.
• W2023362805 cites W1599050967 @default.
• W2023362805 cites W1602445963 @default.
• W2023362805 cites W1972425035 @default.
• W2023362805 cites W1990400645 @default.
• W2023362805 cites W1992494631 @default.
• W2023362805 cites W1996337029 @default.
• W2023362805 cites W2013970992 @default.
• W2023362805 cites W2017055301 @default.
• W2023362805 cites W2018547798 @default.
• W2023362805 cites W2019435702 @default.
• W2023362805 cites W2025012109 @default.
• W2023362805 cites W2053197617 @default.
• W2023362805 cites W2067491528 @default.
• W2023362805 cites W2084519533 @default.
• W2023362805 cites W2179702494 @default.
• W2023362805 doi "https://doi.org/10.1021/bi981547h" @default.
• W2023362805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9819221" @default.
• W2023362805 hasPublicationYear "1998" @default.
• W2023362805 type Work @default.
• W2023362805 sameAs 2023362805 @default.
• W2023362805 citedByCount "31" @default.
• W2023362805 countsByYear W20233628052014 @default.
• W2023362805 countsByYear W20233628052015 @default.
• W2023362805 countsByYear W20233628052016 @default.
• W2023362805 countsByYear W20233628052017 @default.
• W2023362805 countsByYear W20233628052021 @default.
• W2023362805 countsByYear W20233628052022 @default.
• W2023362805 countsByYear W20233628052023 @default.
• W2023362805 crossrefType "journal-article" @default.
• W2023362805 hasAuthorship W2023362805A5024547909 @default.
• W2023362805 hasAuthorship W2023362805A5028940854 @default.
• W2023362805 hasAuthorship W2023362805A5039561796 @default.
• W2023362805 hasAuthorship W2023362805A5083741791 @default.
• W2023362805 hasConcept C116569031 @default.
• W2023362805 hasConcept C120665830 @default.
• W2023362805 hasConcept C121332964 @default.
• W2023362805 hasConcept C170493617 @default.
• W2023362805 hasConcept C173803235 @default.
• W2023362805 hasConcept C178790620 @default.
• W2023362805 hasConcept C181199279 @default.
• W2023362805 hasConcept C185592680 @default.
• W2023362805 hasConcept C187961010 @default.
• W2023362805 hasConcept C2775832776 @default.
• W2023362805 hasConcept C2776217839 @default.
• W2023362805 hasConcept C2778827303 @default.
• W2023362805 hasConcept C2781340169 @default.
• W2023362805 hasConcept C40003534 @default.
• W2023362805 hasConcept C46141821 @default.
• W2023362805 hasConcept C55493867 @default.
• W2023362805 hasConcept C71240020 @default.
• W2023362805 hasConcept C8010536 @default.
• W2023362805 hasConceptScore W2023362805C116569031 @default.
• W2023362805 hasConceptScore W2023362805C120665830 @default.
• W2023362805 hasConceptScore W2023362805C121332964 @default.
• W2023362805 hasConceptScore W2023362805C170493617 @default.
• W2023362805 hasConceptScore W2023362805C173803235 @default.
• W2023362805 hasConceptScore W2023362805C178790620 @default.
• W2023362805 hasConceptScore W2023362805C181199279 @default.
• W2023362805 hasConceptScore W2023362805C185592680 @default.
• W2023362805 hasConceptScore W2023362805C187961010 @default.
• W2023362805 hasConceptScore W2023362805C2775832776 @default.
• W2023362805 hasConceptScore W2023362805C2776217839 @default.
• W2023362805 hasConceptScore W2023362805C2778827303 @default.
• W2023362805 hasConceptScore W2023362805C2781340169 @default.
• W2023362805 hasConceptScore W2023362805C40003534 @default.
• W2023362805 hasConceptScore W2023362805C46141821 @default.
• W2023362805 hasConceptScore W2023362805C55493867 @default.
• W2023362805 hasConceptScore W2023362805C71240020 @default.
• W2023362805 hasConceptScore W2023362805C8010536 @default.
• W2023362805 hasIssue "46" @default.
• W2023362805 hasLocation W20233628051 @default.
• W2023362805 hasLocation W20233628052 @default.
• W2023362805 hasOpenAccess W2023362805 @default.
• W2023362805 hasPrimaryLocation W20233628051 @default.
• W2023362805 hasRelatedWork W1517433011 @default.
• W2023362805 hasRelatedWork W1972493857 @default.
• W2023362805 hasRelatedWork W1982627444 @default.
• W2023362805 hasRelatedWork W1983902512 @default.
• W2023362805 hasRelatedWork W1995375576 @default.
• W2023362805 hasRelatedWork W2016315880 @default.
• W2023362805 hasRelatedWork W2040654790 @default.
• W2023362805 hasRelatedWork W2347063492 @default.
• W2023362805 hasRelatedWork W2517985923 @default.
• W2023362805 hasRelatedWork W3019119561 @default.
• W2023362805 hasVolume "37" @default.
• W2023362805 isParatext "false" @default.

• next