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• W2023362952 abstract "Geissospermum vellosii is a tree widely found throughout the Amazonic forest and frequently used by the native population for painful disorders. The present study examined the antinociceptive effects of Geissospermum vellosii in behavioral models of nociception. Oral administration of crude extract of Geissospermum vellosii or its dichloromethane fraction (1–100 mg/kg) inhibited formalin-induced inflammatory nociception and acetic acid-induced visceral nociception. The antinociceptive effect of Geissospermum vellosii was unrelated with motor dysfunctions. Furthermore, the alkaloid 12-metoxy-1-methyl-aspidospermidine (0.001–1 mg/kg), isolated from the dichloromethane fraction, also produced antinociception. The antinociception caused by the dichloromethane fraction was significantly attenuated by pre-treatment of mice with p-chlorophenylalanine methyl ester (PCPA, an inhibitor of serotonin synthesis, 100 mg/kg once a day for 4 consecutive days) and WAY-100635 (a 5-HT1A receptor antagonist, 0.3 mg/kg). In contrast, dichloromethane fraction antinociception was not affected by pre-treatment of animals with ketanserin (a 5-HT2 receptor antagonist, 0.3 mg/kg) or ondansetron (a 5-HT3 receptor antagonist, 0.5 mg/kg). Together, these results indicate that Geissospermum vellosii produces antinociception through an interaction with 5-HT1A receptors. Furthermore, the alkaloid 12-metoxy-1-methyl-aspidospermidine contributes to the antinociceptive properties reported for Geissospermum vellosii." @default.
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• W2023362952 date "2009-08-01" @default.
• W2023362952 modified "2023-09-25" @default.
• W2023362952 title "Evidence for a role of 5-HT1A receptor on antinociceptive action from Geissospermum vellosii" @default.
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• W2023362952 doi "https://doi.org/10.1016/j.jep.2009.05.026" @default.
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