FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023363028> ?p ?o ?g. }

• W2023363028 endingPage "1576" @default.
• W2023363028 startingPage "1569" @default.
• W2023363028 abstract "We assessed whether the low α-alcohol dehydrogenase (ADH) activity in Japanese (compared with Caucasians) affects the first-pass metabolism of ethanol. ADH isozyme activities were determined in endoscopic biopsies of the gastric corpus from 24 Japanese and 41 Caucasian men by starch gel electrophoresis and by comparing the reduction of m-nitrobenzaldehyde (a preferred substrate of α-ADH) with that of acetaldehyde (a preferred substrate of γ-ADH) and the glutathione-dependent formaldehyde oxidation (a specific reaction of χ-ADH). Alcohol pharmacokinetics was compared in 10 Japanese and 10 Caucasians after administration of ethanol (300 mg/kg of body weight) intravenously or orally, using 5 and 40% oral solutions. Japanese exhibited lower α-ADH activity than Caucasians, with no difference in the other gastric isozymes. With 5% ethanol, first-pass metabolism was strikingly lower in Japanese than in Caucasions. Blood alcohol levels were similar because of the high elimination rate in Japanese due to the hepatic β2-ADH variant. With 40% ethanol, the first-pass metabolism increased in both groups to comparable levels, suggesting an additional contribution by χ-ADH at high ethanol concentrations. These results indicate that α-ADH activity contributes significantly to gastric ethanol oxidation and its lower activity in Japanese is associated with lesser first-pass metabolism." @default.
• W2023363028 created "2016-06-24" @default.
• W2023363028 creator A5000884349 @default.
• W2023363028 creator A5002436824 @default.
• W2023363028 creator A5008348763 @default.
• W2023363028 creator A5045791100 @default.
• W2023363028 creator A5051843684 @default.
• W2023363028 creator A5057659372 @default.
• W2023363028 creator A5069485452 @default.
• W2023363028 creator A5071664461 @default.
• W2023363028 date "1996-12-01" @default.
• W2023363028 modified "2023-10-15" @default.
• W2023363028 title "Ethnic Differences in Gastric α-Alcohol Dehydrogenase Activity and Ethanol First-Pass Metabolism" @default.
• W2023363028 cites W1497645148 @default.
• W2023363028 cites W1575798933 @default.
• W2023363028 cites W1721799416 @default.
• W2023363028 cites W1775749144 @default.
• W2023363028 cites W1923205770 @default.
• W2023363028 cites W1965109741 @default.
• W2023363028 cites W1965977999 @default.
• W2023363028 cites W1966779021 @default.
• W2023363028 cites W1970747424 @default.
• W2023363028 cites W1984562714 @default.
• W2023363028 cites W1985791298 @default.
• W2023363028 cites W1988310257 @default.
• W2023363028 cites W1998329406 @default.
• W2023363028 cites W1999401667 @default.
• W2023363028 cites W2001061306 @default.
• W2023363028 cites W2009310386 @default.
• W2023363028 cites W2046299897 @default.
• W2023363028 cites W2047152595 @default.
• W2023363028 cites W2049695862 @default.
• W2023363028 cites W2057212446 @default.
• W2023363028 cites W2061826207 @default.
• W2023363028 cites W2062716859 @default.
• W2023363028 cites W2083754491 @default.
• W2023363028 cites W2091326633 @default.
• W2023363028 cites W2103664025 @default.
• W2023363028 cites W2109752014 @default.
• W2023363028 cites W2131911594 @default.
• W2023363028 cites W2132716449 @default.
• W2023363028 cites W2149945265 @default.
• W2023363028 cites W2150839687 @default.
• W2023363028 cites W2171810861 @default.
• W2023363028 cites W2407982341 @default.
• W2023363028 doi "https://doi.org/10.1111/j.1530-0277.1996.tb01701.x" @default.
• W2023363028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8986205" @default.
• W2023363028 hasPublicationYear "1996" @default.
• W2023363028 type Work @default.
• W2023363028 sameAs 2023363028 @default.
• W2023363028 citedByCount "102" @default.
• W2023363028 countsByYear W20233630282012 @default.
• W2023363028 countsByYear W20233630282013 @default.
• W2023363028 countsByYear W20233630282014 @default.
• W2023363028 countsByYear W20233630282015 @default.
• W2023363028 countsByYear W20233630282016 @default.
• W2023363028 countsByYear W20233630282017 @default.
• W2023363028 countsByYear W20233630282018 @default.
• W2023363028 countsByYear W20233630282020 @default.
• W2023363028 countsByYear W20233630282023 @default.
• W2023363028 crossrefType "journal-article" @default.
• W2023363028 hasAuthorship W2023363028A5000884349 @default.
• W2023363028 hasAuthorship W2023363028A5002436824 @default.
• W2023363028 hasAuthorship W2023363028A5008348763 @default.
• W2023363028 hasAuthorship W2023363028A5045791100 @default.
• W2023363028 hasAuthorship W2023363028A5051843684 @default.
• W2023363028 hasAuthorship W2023363028A5057659372 @default.
• W2023363028 hasAuthorship W2023363028A5069485452 @default.
• W2023363028 hasAuthorship W2023363028A5071664461 @default.
• W2023363028 hasConcept C119795356 @default.
• W2023363028 hasConcept C126322002 @default.
• W2023363028 hasConcept C134018914 @default.
• W2023363028 hasConcept C181199279 @default.
• W2023363028 hasConcept C185592680 @default.
• W2023363028 hasConcept C25747580 @default.
• W2023363028 hasConcept C2777344606 @default.
• W2023363028 hasConcept C2777595113 @default.
• W2023363028 hasConcept C2780161600 @default.
• W2023363028 hasConcept C2781066024 @default.
• W2023363028 hasConcept C30153976 @default.
• W2023363028 hasConcept C55493867 @default.
• W2023363028 hasConcept C62231903 @default.
• W2023363028 hasConcept C71924100 @default.
• W2023363028 hasConcept C86803240 @default.
• W2023363028 hasConceptScore W2023363028C119795356 @default.
• W2023363028 hasConceptScore W2023363028C126322002 @default.
• W2023363028 hasConceptScore W2023363028C134018914 @default.
• W2023363028 hasConceptScore W2023363028C181199279 @default.
• W2023363028 hasConceptScore W2023363028C185592680 @default.
• W2023363028 hasConceptScore W2023363028C25747580 @default.
• W2023363028 hasConceptScore W2023363028C2777344606 @default.
• W2023363028 hasConceptScore W2023363028C2777595113 @default.
• W2023363028 hasConceptScore W2023363028C2780161600 @default.
• W2023363028 hasConceptScore W2023363028C2781066024 @default.
• W2023363028 hasConceptScore W2023363028C30153976 @default.
• W2023363028 hasConceptScore W2023363028C55493867 @default.
• W2023363028 hasConceptScore W2023363028C62231903 @default.
• W2023363028 hasConceptScore W2023363028C71924100 @default.

• next