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- W2023363208 abstract "It is unknown whether brain affection in myotonic dystrophy type 1 (DM1) and 2 (DM2) is due to neurodevelopmental defects, neurodegeneration or both. Longitudinal imaging studies are missing to date. We performed a longitudinal study to compare changes in cognitive functioning and brain morphology including 16 DM1 (m/f: 6/10, age at baseline 42.48 ± 6.46 years/y, disease duration/DD 13.4 ± 7.5 y), 16 DM2 patients (m/f: 9/7, age 48.49 ± 8.36 y, DD 11.4 ± 9.1 y), and 17 healthy controls (m/f: 9/8, age 50.54 ± 9.78 y). At baseline and 5.45 ± 0.41 y follow-up all subjects underwent neurological and neuropsychological (NP) examinations and 3T-brain magnetic resonance imaging using the identical hard- and software. Diffusion tensor imaging (DTI, Tract Based Spatial Statistics) was conducted to analyse white matter (WM) affection with respect to fractional anisotropy (FA), axial, radial, and mean diffusivity. We used 2-sample t-tests (TT) for group comparisons between patients and controls, and paired t -tests (PT) for longitudinal analyses within each group ( p" @default.
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- W2023363208 date "2014-10-01" @default.
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- W2023363208 title "G.P.130" @default.
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