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- W2023364295 abstract "In the present manuscript we review a substantial body of literature describing several pre-clinical animal models designed and developed with the purpose of investigating the biological determinants of Tourette syndrome (TS). In order to map the animal models onto the theoretical background upon which they have been devised, we first define phenomenological and etiological aspects of TS and then match this information to the available pre-clinical models. Thus, we first describe the characteristic symptoms exhibited by TS patients and then a series of hypotheses attempting to identify the multifactorial causes of TS. With respect to the former, we detail the phenomenology of abnormal repetitive behaviors (tics and stereotypies), obsessive-compulsive behaviors and aberrant sensory-motor gating. With respect to the latter, we describe both potential candidate vulnerability genes and environmental factors (difficult pregnancies, psychosocial stressors and infections). We then discuss how this evidence has been translated in pre-clinical research with respect to both dependent (symptoms) and independent (etiological factors) variables. Thus, while, on the one hand, we detail the methodologies adopted to measure abnormal repetitive and obsessive-compulsive behaviors, and sensory-motor gating, on the other hand, we describe genetic engineering studies and environmental modulations aimed at reproducing the proposed biological determinants in laboratory rodents. A special emphasis is placed upon “programming” events, occurring during critical stages of early development and exerting organizational delayed consequences. In the final section, we outline a heuristic model with the purpose of integrating clinical and pre-clinical evidence in the study of TS." @default.
- W2023364295 created "2016-06-24" @default.
- W2023364295 creator A5007959343 @default.
- W2023364295 creator A5010093730 @default.
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- W2023364295 date "2013-07-01" @default.
- W2023364295 modified "2023-10-16" @default.
- W2023364295 title "Theoretical and practical considerations behind the use of laboratory animals for the study of Tourette syndrome" @default.
- W2023364295 cites W1541784250 @default.
- W2023364295 cites W1546666716 @default.
- W2023364295 cites W1601080250 @default.
- W2023364295 cites W1601979337 @default.
- W2023364295 cites W1605805624 @default.
- W2023364295 cites W1813961414 @default.
- W2023364295 cites W1882556075 @default.
- W2023364295 cites W1897852281 @default.
- W2023364295 cites W1963644974 @default.
- W2023364295 cites W1966281155 @default.
- W2023364295 cites W1967237555 @default.
- W2023364295 cites W1967656014 @default.
- W2023364295 cites W1968902501 @default.
- W2023364295 cites W1970085482 @default.
- W2023364295 cites W1970375293 @default.
- W2023364295 cites W1973250883 @default.
- W2023364295 cites W1974454589 @default.
- W2023364295 cites W1974876676 @default.
- W2023364295 cites W1975717325 @default.
- W2023364295 cites W1976037153 @default.
- W2023364295 cites W1976681768 @default.
- W2023364295 cites W1978326179 @default.
- W2023364295 cites W1978376749 @default.
- W2023364295 cites W1979361034 @default.
- W2023364295 cites W1980506405 @default.
- W2023364295 cites W1981259712 @default.
- W2023364295 cites W198205171 @default.
- W2023364295 cites W1982077726 @default.
- W2023364295 cites W1982462985 @default.
- W2023364295 cites W1984305433 @default.
- W2023364295 cites W1985829096 @default.
- W2023364295 cites W1986130448 @default.
- W2023364295 cites W1987137153 @default.
- W2023364295 cites W1987678122 @default.
- W2023364295 cites W1989662266 @default.
- W2023364295 cites W1991043200 @default.
- W2023364295 cites W1992351676 @default.
- W2023364295 cites W1993797856 @default.
- W2023364295 cites W1994188362 @default.
- W2023364295 cites W1994433943 @default.
- W2023364295 cites W1994982044 @default.
- W2023364295 cites W1996026657 @default.
- W2023364295 cites W1996077055 @default.
- W2023364295 cites W1996281335 @default.
- W2023364295 cites W2000250552 @default.
- W2023364295 cites W2001700591 @default.
- W2023364295 cites W2002182743 @default.
- W2023364295 cites W2002324899 @default.
- W2023364295 cites W2002388836 @default.
- W2023364295 cites W2004104083 @default.
- W2023364295 cites W2004118951 @default.
- W2023364295 cites W2005137616 @default.
- W2023364295 cites W2006578440 @default.
- W2023364295 cites W2007548312 @default.
- W2023364295 cites W2007698371 @default.
- W2023364295 cites W2008127115 @default.
- W2023364295 cites W2009716244 @default.
- W2023364295 cites W2010319576 @default.
- W2023364295 cites W2011436650 @default.
- W2023364295 cites W2011897114 @default.
- W2023364295 cites W2012740861 @default.
- W2023364295 cites W2012866540 @default.
- W2023364295 cites W2014801474 @default.
- W2023364295 cites W2015089523 @default.
- W2023364295 cites W2015540486 @default.
- W2023364295 cites W2016864963 @default.
- W2023364295 cites W2017225090 @default.
- W2023364295 cites W2017263910 @default.
- W2023364295 cites W2018397294 @default.
- W2023364295 cites W2020084640 @default.
- W2023364295 cites W2021194895 @default.
- W2023364295 cites W2022258955 @default.
- W2023364295 cites W2024103960 @default.
- W2023364295 cites W2024301757 @default.
- W2023364295 cites W2025296338 @default.
- W2023364295 cites W2025943863 @default.
- W2023364295 cites W2029277771 @default.
- W2023364295 cites W2031041484 @default.
- W2023364295 cites W2034099200 @default.
- W2023364295 cites W2035229866 @default.
- W2023364295 cites W2037421421 @default.
- W2023364295 cites W2038759008 @default.
- W2023364295 cites W2039198521 @default.
- W2023364295 cites W2040307187 @default.
- W2023364295 cites W2041237576 @default.
- W2023364295 cites W2042196038 @default.
- W2023364295 cites W2042825217 @default.
- W2023364295 cites W2044507912 @default.
- W2023364295 cites W2047844446 @default.
- W2023364295 cites W2048083024 @default.