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• W2023365488 endingPage "2621" @default.
• W2023365488 startingPage "2607" @default.
• W2023365488 abstract "Chromatin modifications have been well-established to play a critical role in the regulation of genome function. Many of these modifications are introduced and removed by enzymes that utilize cofactors derived from primary metabolism. Recently, it has been shown that endogenous cofactors and metabolites can regulate the activity of chromatin-modifying enzymes, providing a direct link between the metabolic state of the cell and epigenetics. Here we review metabolic mechanisms of epigenetic regulation with an emphasis on their role in cancer. Focusing on three core mechanisms, we detail and draw parallels between metabolic and chemical strategies to modulate epigenetic signaling, and highlight opportunities for chemical biologists to help shape our knowledge of this emerging phenomenon. Continuing to integrate our understanding of metabolic and genomic regulatory mechanisms may help elucidate the role of nutrition in diseases such as cancer, while also providing a basis for new approaches to modulate epigenetic signaling for therapeutic benefit." @default.
• W2023365488 created "2016-06-24" @default.
• W2023365488 creator A5062703812 @default.
• W2023365488 date "2013-11-14" @default.
• W2023365488 modified "2023-10-10" @default.
• W2023365488 title "Metabolic Mechanisms of Epigenetic Regulation" @default.
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