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• W2023365912 abstract "This was a small symposium with about 300 delegates, the usual number at the ISSSI series. There were delegates from all the major centres including Professor Hiramatsu’s group in Japan and Professor Hiramatsu gave a lecture on the action of the gene controlling vancomycin resistance. This was a very practical meeting where, for the first time, an international effort was made to link phenotyping and genotyping systems, to report on the international standardization of the latter and to link it both to the epidemiology of the organism and to the patient. The introductory lecture entitled ‘Staphylococci – from patient to gene’ set the scene for the meeting. There were eleven sessions, some running concurrently. Session A concentrated on the epidemiology of, primarily, methicillin-resistant Staphylococcus aureus in both the hospital and the community. Community-acquired infections with MRSA are an increasing problem and, without surveillance, may not be recognized until considerable spread has taken place. Session B looked at the pathogenesis of foreign body infection. The role of the regulator gene (agr) in this process was examined. Session C and D were on animal and human infections respectively. Session C was useful as the similarity between animal and human strains of S. aureus was emphasized. Session D concentrated on bacteraemias (the main risk factor is to be aged over 60). The most significant work presented here was on the development of the vaccine NABISTAPH VAX. Phase II clinical trials have been completed and an immune response has been demonstrated in patients with ESRF but carriage was not cleared. Session E was on resistance to -lactam antibiotics. There were two update lectures on the cell wall of MRSAs and on the origin and spread of the mecA gene. A Norwegian group had characterized the mec gene in hospital isolates of S. epidermidis. Novel primers increased the frequency of detection. Hiramatsu’s co-workers have continued their investigation of the staphylococcal cassette chromosome mec (SCCmec). Thirty-five of 38 strains from 20 countries belonged to one of three types. Session F looked at skin infections. There were reports of super-antigenic strains of S. aureus from eczema, neonatal toxic shock and the effect of wound dressings on the production of TSST-1. Session G examined virulence factors. The search for the ultimate virulence-regulation gene continues. In Session H an attempt was made to marry the old and the new. A group from Oxford had used multi-locus sequence typing to examine strains of S. aureus from the community, communityacquired infections and hospital-acquired infection in the same geographical area. They identified virulent clones within the community, which were related to strains, including EMRSA-15 and EMRSA-16, that cause hospital-acquired infections. The group concluded that some clonal lineages of S. aureus are inherently more virulent than others. An adaptation of binary typing using reversed dot blot of genomic DNA and a typing system based on the dru region of the mec gene are also possibilities for ‘modern’ typing methods. The rest of the session looked at standardization and harmonization of PFGE via either international trials (Europe and the Nordic countries) or indepth local investigations (Scotland). The final sessions were on glycopeptide resistance and the use of newer antibiotics for the treatment of invasive S. aureus infections. The conclusion was that vancomycin is, in the animal model, more" @default.
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• W2023365912 date "2001-01-01" @default.
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• W2023365912 title "Ninth International Symposium on Staphylococci and Staphylococcal Infection (ISSSI), Kolding, Denmark 14–17 June 2000" @default.
• W2023365912 doi "https://doi.org/10.1053/jhin.2000.0870" @default.
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