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- W2023366251 abstract "Background and aim. Radioscintigraphy is the gold standard for evaluation of gastric emptying in children, but requires exposure to ionising radiation. Therefore, the aim of the study was to validate the non-radioactive -acetate breath test in children in comparison to radioscintigraphy as reference method. Patients. Twenty-nine children with dyspeptic or respiratory symptoms were tested for gastric emptying disorders simultaneously performing the -acetate breath test and radioscintigraphy. Methods. A semisolid oatmeal was doubly labelled with 150 mg -acetate and 50 MBq . Breath samples were collected every 5–10 min for 4 h. After mass spectrometrical -analysis, curve fitting of the -cumulative recovery to the modified power exponential function Y=m(1−e−kt)β calculated the half emptying times of the breath test (t1/2breath). Scintigraphic image acquisition began immediately after the ingestion of the -labelled testmeal at a rate of one frame every 60 s for 1 h. Results. Six children showed delayed gastric emptying in scintigraphy (t1/2scinti>60 min). All these children had prolonged half emptying times t1/2breath in the -acetate breath test. Using a cut-off t1/2breath>90 min, the -acetate breath test had a sensitivity of 100% and a specificity of 85%. Scintigraphic and breath test half emptying times were linearly correlated (Y=0.80x+47.68, r=0.76, P<0.00001). Conclusions. The -acetate breath test proves to be a reliable, non-radioactive alternative for measuring gastric emptying in children." @default.
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- W2023366251 date "2004-04-01" @default.
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- W2023366251 title "Measuring gastric emptying of semisolids in children using the 13C-acetate breath test: a validation study" @default.
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- W2023366251 doi "https://doi.org/10.1016/j.dld.2003.12.011" @default.
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