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• W2023366440 abstract "In early-onset myasthenia gravis (EOMG), the thymus is colonized by lymph node-like infiltrates including T cell areas and germinal centers. Our Group1 showed (1978) spontaneous anti-acetylcholine receptor (AChR) autoantibody production by EOMG thymic cells. Especially after enzymic dispersal, these are enriched in plasma cells that are evidently autonomous, long-lived, terminally differentiated and radio-resistant. Radiolabeled AChR is highly sensitive both for localizing them in situ and detecting their ongoing antibody production in culture at limiting cell numbers. Thus EOMG thymi are a readily available source of specific autoimmune human plasma cells suitable for studying their biology and testing new therapies." @default.
• W2023366440 created "2016-06-24" @default.
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• W2023366440 creator A5019704377 @default.
• W2023366440 creator A5034880732 @default.
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• W2023366440 date "2008-09-01" @default.
• W2023366440 modified "2023-09-26" @default.
• W2023366440 title "The myasthenia gravis thymus: A rare source of human autoantibody-secreting plasma cells for testing potential therapeutics" @default.
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• W2023366440 doi "https://doi.org/10.1016/j.jneuroim.2008.06.027" @default.
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