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• W2023367082 abstract "The inhibitory effect of various semi-synthetic derivatives of rifamycin SV on calf thymus DNA-dependent RNA polymerase AI and B activities was investigated. Some of these derivatives having highly hydrophobic side-chains, like AF/013, completely inhibited both types of activities at a concentration of 20 to 40 μg/ml. Initiation, but not elongation, of RNA synthesis was inhibited by these derivatives. Studies on the mode of action of these inhibitors on B enzyme activity have shown that inhibition took place at two steps of the preinitiation process: both the primary binding of enzyme to DNA and a temperature-and time-dependent step were inhibited. After preincubation of B enzymes and calf thymus DNA at 37°C, RNA synthesis was almost completely resistant to AF/013, suggesting that the formation of the resistant complex was related to the opening of the two DNA strands over a short local region at the initiation site. Divalent cations, especially Mn2+, had a marked effect on the formation and the stability of the resistant complex. In the case of enzyme AI some AF/013-resistant RNA synthesis was also observed. However, the same values were obtained whether the preincubation temperature was 37°C or 0°C, indicating that the preinitiation process on calf thymus DNA could be different for the two types of calf thymus RNA polymerase activities." @default.
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• W2023367082 date "1972-07-01" @default.
• W2023367082 modified "2023-09-25" @default.
• W2023367082 title "Animal DNA-Dependent RNA Polymerases. 4. Studies on Inhibition by Rifamycin Derivatives" @default.
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• W2023367082 doi "https://doi.org/10.1111/j.1432-1033.1972.tb01913.x" @default.
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