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- W2023367420 endingPage "159" @default.
- W2023367420 startingPage "149" @default.
- W2023367420 abstract "The present study examined the clock-speed modulating effects of acute cocaine administration in groups of male rats that received different amounts of baseline training on a 36-s peak-interval procedure prior to initial drug injection. After injection of cocaine (10, 15, or 20mg/kg, ip), rats that had received a minimal amount of training (e.g., <or=30 sessions) prior to drug administration displayed a horizontal leftward shift in their timing functions indicating that the speed of the internal clock was increased. In contrast, rats that had received an extended amount of training (e.g., >or=180 sessions) prior to cocaine (15 mg/kg, ip) administration did not produce this classic curve-shift effect, but instead displayed a general disruption of temporal control following drug administration. Importantly, when co-administered with a behaviorally ineffective dose of ketamine (10mg/kg, ip) the ability of cocaine to modulate clock speed in rats receiving extended training was restored. A glutamate lock/unlock hypothesis is used to explain the observed dopamine-glutamate interactions as a function of timing behaviors becoming learned habits." @default.
- W2023367420 created "2016-06-24" @default.
- W2023367420 creator A5015274820 @default.
- W2023367420 creator A5016217969 @default.
- W2023367420 creator A5021489380 @default.
- W2023367420 date "2007-09-01" @default.
- W2023367420 modified "2023-10-18" @default.
- W2023367420 title "Ketamine “unlocks” the reduced clock-speed effects of cocaine following extended training: Evidence for dopamine–glutamate interactions in timing and time perception" @default.
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