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• W2023370536 abstract "Cigarette smoke is a major risk factor for lung cancer and respiratory infections. This increased susceptibility may result from cigarette smoke-induced impairment of the immune system. In this study, we evaluated the effect of nicotine on the production of inflammatory mediators by activated macrophages. Pretreatment with nicotine caused a significant inhibition of LPS-induced IL-1, IL-8, and PGE2 expression at the transcriptional level in U937 cells. Nicotine inhibited the activation of a transcription factor, NF-kappaB, which in turn, binds to and mediates transcriptional activation of these genes. These inhibitory effects of nicotine may contribute to cigarette smoke-induced immunosuppression." @default.
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• W2023370536 date "1998-11-01" @default.
• W2023370536 modified "2023-10-09" @default.
• W2023370536 title "Nicotine Inhibits the Production of Inflammatory Mediators in U937 Cells through Modulation of Nuclear Factor-kB Activation" @default.
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• W2023370536 doi "https://doi.org/10.1006/bbrc.1998.9599" @default.
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