Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023371306> ?p ?o ?g. }
- W2023371306 endingPage "14" @default.
- W2023371306 startingPage "1" @default.
- W2023371306 abstract "Many studies have indicated that the inability of adult mammalian central nervous system (CNS) to regenerate after injury is partly due to the existence of growth-inhibitory molecules associated with CNS myelin. Studies over the years have led to the identification of multiple myelin-associated inhibitors, among which Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (Omgp) represent potentially major contributors to CNS axon regeneration failure. Here we review in vitro and in vivo investigations into these inhibitory ligands and their functional mechanisms, focusing particularly on the neuronal receptors that mediate the inhibitory signals from these myelin molecules. A better understanding of the receptors for myelin-associated inhibitors could provide opportunities to decipher the mechanism of restriction in CNS regeneration, and lead to the development of potential therapeutic targets in neurodegenerative diseases and neurological injury. We will discuss the structures of the receptors and therapeutic opportunities that might arise based on this information." @default.
- W2023371306 created "2016-06-24" @default.
- W2023371306 creator A5001349527 @default.
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- W2023371306 creator A5023043669 @default.
- W2023371306 creator A5033458532 @default.
- W2023371306 creator A5043876952 @default.
- W2023371306 creator A5048436530 @default.
- W2023371306 date "2010-01-01" @default.
- W2023371306 modified "2023-09-26" @default.
- W2023371306 title "Receptors for myelin inhibitors: Structures and therapeutic opportunities" @default.
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