Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023371405> ?p ?o ?g. }
- W2023371405 endingPage "26410" @default.
- W2023371405 startingPage "26402" @default.
- W2023371405 abstract "The Ecdysoneless (Ecd) protein is required for cell-autonomous roles in development and oogenesis in Drosophila, but the function of its evolutionarily conserved mammalian orthologs is not clear. To study the cellular function of Ecd in mammalian cells, we generated Ecd(lox/lox) mouse embryonic fibroblast cells from Ecd floxed mouse embryos. Cre-mediated deletion of Ecd in Ecd(lox/lox) mouse embryonic fibroblasts led to a proliferative block due to a delay in G(1)-S cell cycle progression; this defect was reversed by the introduction of human Ecd. Loss of Ecd led to marked down-regulation of E2F target gene expression. Furthermore, Ecd directly bound to Rb at the pocket domain and competed with E2F for binding to hypophosphorylated Rb. Our results demonstrate that mammalian Ecd plays a role in cell cycle progression via the Rb-E2F pathway." @default.
- W2023371405 created "2016-06-24" @default.
- W2023371405 creator A5030923074 @default.
- W2023371405 creator A5031432482 @default.
- W2023371405 creator A5042973046 @default.
- W2023371405 creator A5045641166 @default.
- W2023371405 creator A5048258172 @default.
- W2023371405 creator A5049872167 @default.
- W2023371405 creator A5072324344 @default.
- W2023371405 creator A5078669073 @default.
- W2023371405 date "2009-09-01" @default.
- W2023371405 modified "2023-10-12" @default.
- W2023371405 title "Role of Mammalian Ecdysoneless in Cell Cycle Regulation" @default.
- W2023371405 cites W1864666401 @default.
- W2023371405 cites W1918497631 @default.
- W2023371405 cites W1979051583 @default.
- W2023371405 cites W1979431065 @default.
- W2023371405 cites W1982166284 @default.
- W2023371405 cites W1993492313 @default.
- W2023371405 cites W1998492363 @default.
- W2023371405 cites W1999330214 @default.
- W2023371405 cites W2001627329 @default.
- W2023371405 cites W2007788159 @default.
- W2023371405 cites W2012994175 @default.
- W2023371405 cites W2013298337 @default.
- W2023371405 cites W2023806904 @default.
- W2023371405 cites W2028612559 @default.
- W2023371405 cites W2032096932 @default.
- W2023371405 cites W2033369330 @default.
- W2023371405 cites W2034277114 @default.
- W2023371405 cites W2035066068 @default.
- W2023371405 cites W2049783958 @default.
- W2023371405 cites W2055162988 @default.
- W2023371405 cites W2066115808 @default.
- W2023371405 cites W2078066154 @default.
- W2023371405 cites W2081412587 @default.
- W2023371405 cites W2082382637 @default.
- W2023371405 cites W2093093221 @default.
- W2023371405 cites W2094450275 @default.
- W2023371405 cites W2098765233 @default.
- W2023371405 cites W2112624449 @default.
- W2023371405 cites W2131954674 @default.
- W2023371405 cites W2132641868 @default.
- W2023371405 cites W2149139293 @default.
- W2023371405 cites W2151812144 @default.
- W2023371405 cites W2155775021 @default.
- W2023371405 cites W2171756101 @default.
- W2023371405 cites W2262513754 @default.
- W2023371405 cites W30682660 @default.
- W2023371405 doi "https://doi.org/10.1074/jbc.m109.030551" @default.
- W2023371405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2785328" @default.
- W2023371405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19640839" @default.
- W2023371405 hasPublicationYear "2009" @default.
- W2023371405 type Work @default.
- W2023371405 sameAs 2023371405 @default.
- W2023371405 citedByCount "26" @default.
- W2023371405 countsByYear W20233714052012 @default.
- W2023371405 countsByYear W20233714052013 @default.
- W2023371405 countsByYear W20233714052014 @default.
- W2023371405 countsByYear W20233714052015 @default.
- W2023371405 countsByYear W20233714052016 @default.
- W2023371405 countsByYear W20233714052017 @default.
- W2023371405 countsByYear W20233714052018 @default.
- W2023371405 countsByYear W20233714052019 @default.
- W2023371405 countsByYear W20233714052020 @default.
- W2023371405 countsByYear W20233714052021 @default.
- W2023371405 countsByYear W20233714052022 @default.
- W2023371405 countsByYear W20233714052023 @default.
- W2023371405 crossrefType "journal-article" @default.
- W2023371405 hasAuthorship W2023371405A5030923074 @default.
- W2023371405 hasAuthorship W2023371405A5031432482 @default.
- W2023371405 hasAuthorship W2023371405A5042973046 @default.
- W2023371405 hasAuthorship W2023371405A5045641166 @default.
- W2023371405 hasAuthorship W2023371405A5048258172 @default.
- W2023371405 hasAuthorship W2023371405A5049872167 @default.
- W2023371405 hasAuthorship W2023371405A5072324344 @default.
- W2023371405 hasAuthorship W2023371405A5078669073 @default.
- W2023371405 hasBestOaLocation W20233714051 @default.
- W2023371405 hasConcept C104317684 @default.
- W2023371405 hasConcept C14036430 @default.
- W2023371405 hasConcept C145103041 @default.
- W2023371405 hasConcept C29537977 @default.
- W2023371405 hasConcept C54355233 @default.
- W2023371405 hasConcept C83258922 @default.
- W2023371405 hasConcept C86803240 @default.
- W2023371405 hasConcept C95444343 @default.
- W2023371405 hasConceptScore W2023371405C104317684 @default.
- W2023371405 hasConceptScore W2023371405C14036430 @default.
- W2023371405 hasConceptScore W2023371405C145103041 @default.
- W2023371405 hasConceptScore W2023371405C29537977 @default.
- W2023371405 hasConceptScore W2023371405C54355233 @default.
- W2023371405 hasConceptScore W2023371405C83258922 @default.
- W2023371405 hasConceptScore W2023371405C86803240 @default.
- W2023371405 hasConceptScore W2023371405C95444343 @default.
- W2023371405 hasIssue "39" @default.
- W2023371405 hasLocation W20233714051 @default.
- W2023371405 hasLocation W20233714052 @default.
- W2023371405 hasLocation W20233714053 @default.