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• W2023371632 endingPage "790" @default.
• W2023371632 startingPage "775" @default.
• W2023371632 abstract "Serotonin receptors (5-HTRs) are known to be involved in the regulation of breathing behavior and to mediate neurotrophic actions that exert a significant function in network formation during development. We studied neuronal 5-HT4(a)R-immunoreactivity (-IR) at developmental ages from E14 to P10. Within the pre-Bötzinger complex (pre-BötC), a part of the respiratory network important for rhythmogenesis, 5-HT4(a)R-IR was most extensive in rats at an age of E18. The 5-HT4(a)-IR was found predominantly in the neuropil, whereas somatic staining was sporadic at late embryonic (E18–E20) stages. At birth, we observed a dramatic change to a predominantly somatic staining, and neuropil staining was greatly reduced and disappeared at an age of P4. In all developmental stages, 5-HT4(a) and μ-opioid receptors were strongly coexpressed in neurons of the pre-BötC, whereas 5-HT4(a)R expression was absent in neurons within the dorsal horn. Nestin, a marker for CNS progenitor cells, was used to obtain information about the degree of pre-BötC differentiation. Nestin-positive cells did not appear within the pre-BötC before age E20. At E16, nestin-expressing cells were absent in the nucleus ambiguus (NA) and its ventral periphery. The number of nestin-positive cells increased after birth within and outside the pre-BötC, the majority of cells being glial. Coexpression of nestin and 5-HT4(a)R was localized predominantly within the NA and appeared only sporadically within the pre-BötC. We conclude that 5-HT4(a)Rs are important not only for neuromodulation of cellular excitability but also for respiratory network formation. J. Comp. Neurol. 506:775–790, 2008. © 2007 Wiley-Liss, Inc." @default.
• W2023371632 created "2016-06-24" @default.
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• W2023371632 date "2007-01-01" @default.
• W2023371632 modified "2023-10-15" @default.
• W2023371632 title "Developmental changes of serotonin 4(a) receptor expression in the rat pre-Bötzinger complex" @default.
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• W2023371632 doi "https://doi.org/10.1002/cne.21581" @default.
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