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• W2023371690 abstract "Recombinant (r)-hirudin is a specific inhibitor of thrombin that is independent of the activity of antithrombin.To evaluate pharmacokinetic properties and coagulatory changes of r-hirudin in healthy horses.Two clinically healthy horses received a single i.v. bolus of 0.4 mg/kg bwt r-hirudin and 6 clinically healthy horses received the same dose subcutaneously (subcut.) q. 12 h for 3 days. Coagulation times and r-hirudin plasma concentration were determined over 720 mins and 3 days after i.v. and subcut. administration, respectively.In all horses, treatment with r-hirudin was not associated with systemic or local side effects. After i.v. injection, the 2 horses showed an elimination half-life of 58 and 80 mins, respectively. After subcut. administration, maximum plasma concentration of r-hirudin occurred at 128 +/- 55 mins and declined with a terminal half-life of 561 +/- 364 mins. Maximum response of activated partial thromboplastin time (aPTT) occurred 1.5 h after administration of r-hirudin. A prolongation of 1.9 +/- 0.2 times the pretreatment value was noted.Pharmacokinetics of r-hirudin in healthy horses were similar to those in man and other animal species.The results of this study indicate that r-hirudin can be used in horses, but further studies should be performed in order to prove its effectiveness in diseased horses." @default.
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• W2023371690 date "2010-01-05" @default.
• W2023371690 modified "2023-10-02" @default.
• W2023371690 title "Pharmacokinetics of recombinant hirudin in healthy horses" @default.
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• W2023371690 doi "https://doi.org/10.2746/0425164044868666" @default.
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