FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023371975> ?p ?o ?g. }

• W2023371975 endingPage "41" @default.
• W2023371975 startingPage "31" @default.
• W2023371975 abstract "Vascular endothelial growth factor (VEGF) plays a fundamental role in mediating tumor angiogenesis and tumor growth. Here we investigate the direct effect of a novel small molecule inhibitor of the Flk-1-mediated signal transduction pathway of VEGF, SU5416, on tumor angiogenesis and microhemodynamics of an experimental glioblastoma by using intravital multifluorescence videomicroscopy. SU5416 treatment significantly suppressed tumor growth. In parallel, SU5416 demonstrated a potent antiangiogenic activity, resulting in a significant reduction of both the total and functional vascular density of the tumor microvasculature, which indicates an impaired vascularization as well as significant perfusion failure in treated tumors. This malperfusion was not compensated for by changes in vessel diameter or recruitment of nonperfused vessels. Analyses of the tumor microcirculation revealed significant microhemodynamic changes after angiogenesis blockage such as a higher red blood cell velocity and blood flow in remnant tumor vessels when compared with controls. Our results demonstrate that the novel antiangiogenic concept of targeting the tyrosine kinase of Flk-1/KDR by means of a small molecule inhibitor represents an efficient strategy to control growth and progression of angiogenesis-dependent tumors. This study provides insight into microvascular consequences of Flk-1/KDR targeting in vivo and may have important implications for the future treatment of angiogenesis-dependent neoplasms." @default.
• W2023371975 created "2016-06-24" @default.
• W2023371975 creator A5002844010 @default.
• W2023371975 creator A5006454522 @default.
• W2023371975 creator A5007378676 @default.
• W2023371975 creator A5050478407 @default.
• W2023371975 creator A5070250547 @default.
• W2023371975 creator A5081747456 @default.
• W2023371975 creator A5084846736 @default.
• W2023371975 creator A5090328045 @default.
• W2023371975 date "1999-04-01" @default.
• W2023371975 modified "2023-10-18" @default.
• W2023371975 title "Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the Novel Flk-1 Inhibitor SU5416 as Assessed by Intravital Multi-fluorescence Videomicroscopy" @default.
• W2023371975 cites W1480012785 @default.
• W2023371975 cites W1485571149 @default.
• W2023371975 cites W1508582865 @default.
• W2023371975 cites W1675889352 @default.
• W2023371975 cites W1865108675 @default.
• W2023371975 cites W1917703525 @default.
• W2023371975 cites W1918669574 @default.
• W2023371975 cites W1964084343 @default.
• W2023371975 cites W1966949779 @default.
• W2023371975 cites W1969328947 @default.
• W2023371975 cites W1975907727 @default.
• W2023371975 cites W1986559037 @default.
• W2023371975 cites W1986758971 @default.
• W2023371975 cites W1986812997 @default.
• W2023371975 cites W1989617588 @default.
• W2023371975 cites W1990271674 @default.
• W2023371975 cites W1991958278 @default.
• W2023371975 cites W1992388470 @default.
• W2023371975 cites W1994131389 @default.
• W2023371975 cites W2000000541 @default.
• W2023371975 cites W2003598961 @default.
• W2023371975 cites W2011528240 @default.
• W2023371975 cites W2015344488 @default.
• W2023371975 cites W2019273955 @default.
• W2023371975 cites W2021954150 @default.
• W2023371975 cites W2029763523 @default.
• W2023371975 cites W2032359283 @default.
• W2023371975 cites W2043850275 @default.
• W2023371975 cites W2043863730 @default.
• W2023371975 cites W2047746573 @default.
• W2023371975 cites W2050358495 @default.
• W2023371975 cites W2052582923 @default.
• W2023371975 cites W2053375897 @default.
• W2023371975 cites W2058839845 @default.
• W2023371975 cites W2063066157 @default.
• W2023371975 cites W2064739543 @default.
• W2023371975 cites W2072883274 @default.
• W2023371975 cites W2084506573 @default.
• W2023371975 cites W2108145145 @default.
• W2023371975 cites W2114114940 @default.
• W2023371975 cites W2119423559 @default.
• W2023371975 cites W2122226633 @default.
• W2023371975 cites W2144383844 @default.
• W2023371975 cites W2146133225 @default.
• W2023371975 cites W2158743409 @default.
• W2023371975 cites W2166156136 @default.
• W2023371975 cites W2166825418 @default.
• W2023371975 cites W2201499962 @default.
• W2023371975 cites W2246750528 @default.
• W2023371975 cites W2337452960 @default.
• W2023371975 cites W2885241976 @default.
• W2023371975 cites W3020922425 @default.
• W2023371975 cites W4255042798 @default.
• W2023371975 doi "https://doi.org/10.1038/sj.neo.7900006" @default.
• W2023371975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1716058" @default.
• W2023371975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10935468" @default.
• W2023371975 hasPublicationYear "1999" @default.
• W2023371975 type Work @default.
• W2023371975 sameAs 2023371975 @default.
• W2023371975 citedByCount "137" @default.
• W2023371975 countsByYear W20233719752012 @default.
• W2023371975 countsByYear W20233719752013 @default.
• W2023371975 countsByYear W20233719752014 @default.
• W2023371975 countsByYear W20233719752015 @default.
• W2023371975 countsByYear W20233719752016 @default.
• W2023371975 countsByYear W20233719752018 @default.
• W2023371975 countsByYear W20233719752019 @default.
• W2023371975 countsByYear W20233719752020 @default.
• W2023371975 countsByYear W20233719752021 @default.
• W2023371975 countsByYear W20233719752022 @default.
• W2023371975 crossrefType "journal-article" @default.
• W2023371975 hasAuthorship W2023371975A5002844010 @default.
• W2023371975 hasAuthorship W2023371975A5006454522 @default.
• W2023371975 hasAuthorship W2023371975A5007378676 @default.
• W2023371975 hasAuthorship W2023371975A5050478407 @default.
• W2023371975 hasAuthorship W2023371975A5070250547 @default.
• W2023371975 hasAuthorship W2023371975A5081747456 @default.
• W2023371975 hasAuthorship W2023371975A5084846736 @default.
• W2023371975 hasAuthorship W2023371975A5090328045 @default.
• W2023371975 hasBestOaLocation W20233719751 @default.
• W2023371975 hasConcept C121608353 @default.
• W2023371975 hasConcept C123012128 @default.
• W2023371975 hasConcept C126322002 @default.
• W2023371975 hasConcept C12722491 @default.
• W2023371975 hasConcept C134018914 @default.

• next