FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023372225> ?p ?o ?g. }

• W2023372225 endingPage "88" @default.
• W2023372225 startingPage "82" @default.
• W2023372225 abstract "In this study, the effects of combination therapy consisting of X-ray irradiation and Z-100 on the survival time of C57BL/6 mice inoculated with B16F10 melanoma were investigated. Survival time was significantly prolonged in B16F10 melanoma-bearing mice treated with the X-ray irradiation (5 Gy) and Z-100 (10 mg/kg s.c.) combination therapy compared with mice irradiated with X-rays alone. The weight of primary tumors and number of metastatic colonies were also significantly suppressed by the combination therapy compared with that in the X-ray irradiation group. These results indicated that Z-100 could enhance the anti-tumor effects of radiotherapy against B16F10 melanoma. On the other hand, the survival time of CD4 knockout mice bearing the same tumors was not prolonged by the combination therapy compared with mice irradiated with X-rays alone, suggesting that CD4+ cells are partly involved in augmentation of the anti-tumor effect of radiotherapy by Z-100. In addition, type 1 cytokine (IL-2, IFN-γ) production was significantly increased and type 2 cytokine (IL-4, IL-10) production was significantly suppressed in the tumor-bearing mice treated with the combination therapy compared with the X-ray irradiation group. Moreover, interleukin-12 production by CD11c+ cells was also significantly increased in mice treated with the combination therapy compared with the X-ray irradiation group. These results indicate that Z-100 augmented the anti-tumor effects of X-ray irradiation. Moreover, we demonstrated that the effects of Z-100 were expressed at least in part, by the improvement of the T cell responses from type 2-dominant to type 1-dominant via up-regulation of IL-12 production." @default.
• W2023372225 created "2016-06-24" @default.
• W2023372225 creator A5020105606 @default.
• W2023372225 creator A5027517892 @default.
• W2023372225 creator A5046099195 @default.
• W2023372225 creator A5051886440 @default.
• W2023372225 creator A5064407359 @default.
• W2023372225 creator A5082357754 @default.
• W2023372225 date "2004-01-01" @default.
• W2023372225 modified "2023-09-27" @default.
• W2023372225 title "Z-100, an Immunomodulatory Arabinomannan Extracted from Mycobacterium tuberculosis Strain Aoyama B, Augments Anti-tumor Activities of X-Ray Irradiation against B16 Melanoma in Association with the Improvement of Type 1T Cell Responses" @default.
• W2023372225 cites W1601925808 @default.
• W2023372225 cites W1903411571 @default.
• W2023372225 cites W1942668068 @default.
• W2023372225 cites W1965018433 @default.
• W2023372225 cites W1979316085 @default.
• W2023372225 cites W1979514172 @default.
• W2023372225 cites W1984729161 @default.
• W2023372225 cites W1986858811 @default.
• W2023372225 cites W1989917013 @default.
• W2023372225 cites W1991463784 @default.
• W2023372225 cites W1996517462 @default.
• W2023372225 cites W2000052279 @default.
• W2023372225 cites W2006949288 @default.
• W2023372225 cites W2007867627 @default.
• W2023372225 cites W2011682689 @default.
• W2023372225 cites W2017591700 @default.
• W2023372225 cites W2030025795 @default.
• W2023372225 cites W2033020007 @default.
• W2023372225 cites W2035636047 @default.
• W2023372225 cites W2048590540 @default.
• W2023372225 cites W2058792639 @default.
• W2023372225 cites W2059634742 @default.
• W2023372225 cites W2066070404 @default.
• W2023372225 cites W2072929746 @default.
• W2023372225 cites W2081517806 @default.
• W2023372225 cites W2084990572 @default.
• W2023372225 cites W2090808570 @default.
• W2023372225 cites W2095406952 @default.
• W2023372225 cites W2102156468 @default.
• W2023372225 cites W2128321311 @default.
• W2023372225 cites W2141372992 @default.
• W2023372225 cites W2151707711 @default.
• W2023372225 cites W2161485037 @default.
• W2023372225 cites W2922282144 @default.
• W2023372225 cites W3026660513 @default.
• W2023372225 cites W4231711865 @default.
• W2023372225 doi "https://doi.org/10.1248/bpb.27.82" @default.
• W2023372225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14709904" @default.
• W2023372225 hasPublicationYear "2004" @default.
• W2023372225 type Work @default.
• W2023372225 sameAs 2023372225 @default.
• W2023372225 citedByCount "21" @default.
• W2023372225 countsByYear W20233722252012 @default.
• W2023372225 countsByYear W20233722252013 @default.
• W2023372225 countsByYear W20233722252014 @default.
• W2023372225 countsByYear W20233722252015 @default.
• W2023372225 countsByYear W20233722252020 @default.
• W2023372225 countsByYear W20233722252021 @default.
• W2023372225 countsByYear W20233722252022 @default.
• W2023372225 crossrefType "journal-article" @default.
• W2023372225 hasAuthorship W2023372225A5020105606 @default.
• W2023372225 hasAuthorship W2023372225A5027517892 @default.
• W2023372225 hasAuthorship W2023372225A5046099195 @default.
• W2023372225 hasAuthorship W2023372225A5051886440 @default.
• W2023372225 hasAuthorship W2023372225A5064407359 @default.
• W2023372225 hasAuthorship W2023372225A5082357754 @default.
• W2023372225 hasBestOaLocation W20233722251 @default.
• W2023372225 hasConcept C111337013 @default.
• W2023372225 hasConcept C121332964 @default.
• W2023372225 hasConcept C126322002 @default.
• W2023372225 hasConcept C185544564 @default.
• W2023372225 hasConcept C185592680 @default.
• W2023372225 hasConcept C203014093 @default.
• W2023372225 hasConcept C2776999253 @default.
• W2023372225 hasConcept C2777658100 @default.
• W2023372225 hasConcept C2778690821 @default.
• W2023372225 hasConcept C502942594 @default.
• W2023372225 hasConcept C509974204 @default.
• W2023372225 hasConcept C71924100 @default.
• W2023372225 hasConceptScore W2023372225C111337013 @default.
• W2023372225 hasConceptScore W2023372225C121332964 @default.
• W2023372225 hasConceptScore W2023372225C126322002 @default.
• W2023372225 hasConceptScore W2023372225C185544564 @default.
• W2023372225 hasConceptScore W2023372225C185592680 @default.
• W2023372225 hasConceptScore W2023372225C203014093 @default.
• W2023372225 hasConceptScore W2023372225C2776999253 @default.
• W2023372225 hasConceptScore W2023372225C2777658100 @default.
• W2023372225 hasConceptScore W2023372225C2778690821 @default.
• W2023372225 hasConceptScore W2023372225C502942594 @default.
• W2023372225 hasConceptScore W2023372225C509974204 @default.
• W2023372225 hasConceptScore W2023372225C71924100 @default.
• W2023372225 hasIssue "1" @default.
• W2023372225 hasLocation W20233722251 @default.
• W2023372225 hasLocation W20233722252 @default.
• W2023372225 hasOpenAccess W2023372225 @default.
• W2023372225 hasPrimaryLocation W20233722251 @default.
• W2023372225 hasRelatedWork W1527365325 @default.

• next