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- W2023374122 abstract "You have accessJournal of UrologyProstate Cancer: Epidemiology and Natural History1 Apr 2011463 THE ASSOCIATION BETWEEN ANDROGEN DEPRIVATION AND CARDIOVASCULAR EVENTS IN A POPULATION BASED COHORT WITH LONG TERM FOLLOW-UP Rodney Breau, Brant Inman, Ajay Nehra, Jennifer St. Sauver, Laureano Rangel, Rachel Carlson, R. Jeffrey Karnes, and Eric Bergstralh Rodney BreauRodney Breau Ottawa, Canada More articles by this author , Brant InmanBrant Inman Durham, NC More articles by this author , Ajay NehraAjay Nehra Rochester, MN More articles by this author , Jennifer St. SauverJennifer St. Sauver Rochester, MN More articles by this author , Laureano RangelLaureano Rangel Rochester, MN More articles by this author , Rachel CarlsonRachel Carlson Rochester, MN More articles by this author , R. Jeffrey KarnesR. Jeffrey Karnes Rochester, MN More articles by this author , and Eric BergstralhEric Bergstralh Rochester, MN More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.556AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The purpose of this study was to determine the association between androgen deprivation and selected cardiovascular events in men with prostate cancer. METHODS Using the Rochester Epidemiology Project record linkage system, all men with pathologically confirmed prostate cancer between 1983 and 1997 were identified. In 2009, all medical records were reviewed for use of androgen deprivation (LHRH agonists or orchiectomy) and incidence of myocardial infarction (MI), cerebrovascular accident (CVA), congestive heart failure (CHF) or cardiovascular death. Androgen deprivation was analyzed as a time dependent covariate and all associations presented are adjusted for age, diabetes, hypertension, hyperlipidemia, obesity, chronic kidney disease and tobacco use. RESULTS During the study period, 869 men were diagnosed with prostate cancer and 311 (36%) were treated with androgen deprivation at a median follow-up of 10.4 years. The incidence of events was: 121 MI, 178 CVA, 211 CHF and 132 cardiovascular deaths. The adjusted associations between androgen deprivation and cardiovascular events are shown in the table below. Associations between androgen deprivation and cardiovascular events Outcome LHRH Agonist Orchiectomy Myocardial infarction 0.61(0.28,1.32) 1.08(0.68,1.71) Cerebrovascular accident 0.77(0.44,1.38) 0.86(0.58,1.27) Congestive heart failure 1.66(1.08,2.57) 1.38(0.99,1.93) Cardiovascular death 0.51(0.23,1.10) 0.86(0.55,1.33) Adjusted HR (95Confidence Interval) CONCLUSIONS Androgen deprivation was associated with a modest increased risk of CHF, but not MI, CVA, or cardiovascular death. These data support the continued use of androgen deprivation in prostate cancer patients when clinically indicated. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e188 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Metrics Author Information Rodney Breau Ottawa, Canada More articles by this author Brant Inman Durham, NC More articles by this author Ajay Nehra Rochester, MN More articles by this author Jennifer St. Sauver Rochester, MN More articles by this author Laureano Rangel Rochester, MN More articles by this author Rachel Carlson Rochester, MN More articles by this author R. Jeffrey Karnes Rochester, MN More articles by this author Eric Bergstralh Rochester, MN More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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