FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023374876> ?p ?o ?g. }

• W2023374876 endingPage "807" @default.
• W2023374876 startingPage "800" @default.
• W2023374876 abstract "The transcription factor C/EBPalpha (CEBPA) is a key player in granulopoiesis and leukemogenesis. We have previously reported the interaction of C/EBPalpha with other proteins (utilizing mass spectrometry) in transcriptional regulation. In the present study, we characterized the association of the MYST domain histone acetyltransferase Tat-interactive protein (TIP) 60 (HTATIP) with C/EBPalpha. We show in pull-down and co-precipitation experiments that C/EBPalpha and HTATIP interact. A chromatin immunoprecipitation (ChIP) and a confirmatory Re-ChIP assay revealed in vivo occupancy of the C/EBPalpha and GCSF-R promoter by HTATIP. Reporter gene assays showed that HTATIP is a co-activator of C/EBPalpha. The co-activator function of HTATIP is dependent on its intact histone acetyltransferase (HAT) domain and on the C/EBPalpha DNA-binding domain. The resulting balance between histone acetylation and deacetylation at the C/EBPalpha promoter might represent an important mechanism of C/EBPalpha action. We observed a lower expression of HTATIP mRNA in undifferentiated U937 cells compared to retinoic acid-induced differentiated U937 cells, and correlated expression of CEBPA and HTATIP mRNA levels were observed in leukemia samples. These findings point to a functional synergism between C/EBPalpha and HTATIP in myeloid differentiation and suggest that HTATIP might be an important player in leukemogenesis." @default.
• W2023374876 created "2016-06-24" @default.
• W2023374876 creator A5010063085 @default.
• W2023374876 creator A5011513433 @default.
• W2023374876 creator A5030808762 @default.
• W2023374876 creator A5031660112 @default.
• W2023374876 creator A5033935778 @default.
• W2023374876 creator A5058099757 @default.
• W2023374876 creator A5064722914 @default.
• W2023374876 creator A5077983706 @default.
• W2023374876 creator A5088477700 @default.
• W2023374876 date "2008-01-31" @default.
• W2023374876 modified "2023-10-14" @default.
• W2023374876 title "Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPα" @default.
• W2023374876 cites W1489323849 @default.
• W2023374876 cites W1502074492 @default.
• W2023374876 cites W1973942683 @default.
• W2023374876 cites W1975601584 @default.
• W2023374876 cites W1978340298 @default.
• W2023374876 cites W1984246427 @default.
• W2023374876 cites W1987598864 @default.
• W2023374876 cites W2004450968 @default.
• W2023374876 cites W2005902803 @default.
• W2023374876 cites W2008979272 @default.
• W2023374876 cites W2036641082 @default.
• W2023374876 cites W2036883820 @default.
• W2023374876 cites W2048920286 @default.
• W2023374876 cites W2058189438 @default.
• W2023374876 cites W2058356488 @default.
• W2023374876 cites W2070399051 @default.
• W2023374876 cites W2086524102 @default.
• W2023374876 cites W2100088478 @default.
• W2023374876 cites W2105214585 @default.
• W2023374876 cites W2113470975 @default.
• W2023374876 cites W2119008464 @default.
• W2023374876 cites W2120948678 @default.
• W2023374876 cites W2122706742 @default.
• W2023374876 cites W2127632559 @default.
• W2023374876 cites W2150702851 @default.
• W2023374876 cites W2164333337 @default.
• W2023374876 cites W84003226 @default.
• W2023374876 doi "https://doi.org/10.1038/sj.leu.2405101" @default.
• W2023374876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18239623" @default.
• W2023374876 hasPublicationYear "2008" @default.
• W2023374876 type Work @default.
• W2023374876 sameAs 2023374876 @default.
• W2023374876 citedByCount "44" @default.
• W2023374876 countsByYear W20233748762012 @default.
• W2023374876 countsByYear W20233748762013 @default.
• W2023374876 countsByYear W20233748762014 @default.
• W2023374876 countsByYear W20233748762015 @default.
• W2023374876 countsByYear W20233748762016 @default.
• W2023374876 countsByYear W20233748762017 @default.
• W2023374876 countsByYear W20233748762018 @default.
• W2023374876 countsByYear W20233748762019 @default.
• W2023374876 countsByYear W20233748762020 @default.
• W2023374876 countsByYear W20233748762021 @default.
• W2023374876 crossrefType "journal-article" @default.
• W2023374876 hasAuthorship W2023374876A5010063085 @default.
• W2023374876 hasAuthorship W2023374876A5011513433 @default.
• W2023374876 hasAuthorship W2023374876A5030808762 @default.
• W2023374876 hasAuthorship W2023374876A5031660112 @default.
• W2023374876 hasAuthorship W2023374876A5033935778 @default.
• W2023374876 hasAuthorship W2023374876A5058099757 @default.
• W2023374876 hasAuthorship W2023374876A5064722914 @default.
• W2023374876 hasAuthorship W2023374876A5077983706 @default.
• W2023374876 hasAuthorship W2023374876A5088477700 @default.
• W2023374876 hasBestOaLocation W20233748761 @default.
• W2023374876 hasConcept C101762097 @default.
• W2023374876 hasConcept C104317684 @default.
• W2023374876 hasConcept C119157956 @default.
• W2023374876 hasConcept C134320426 @default.
• W2023374876 hasConcept C149240914 @default.
• W2023374876 hasConcept C150194340 @default.
• W2023374876 hasConcept C153911025 @default.
• W2023374876 hasConcept C185592680 @default.
• W2023374876 hasConcept C2777865847 @default.
• W2023374876 hasConcept C2778001298 @default.
• W2023374876 hasConcept C2778305200 @default.
• W2023374876 hasConcept C29512474 @default.
• W2023374876 hasConcept C45091340 @default.
• W2023374876 hasConcept C55493867 @default.
• W2023374876 hasConcept C64927066 @default.
• W2023374876 hasConcept C83640560 @default.
• W2023374876 hasConcept C86339819 @default.
• W2023374876 hasConcept C86803240 @default.
• W2023374876 hasConcept C88045685 @default.
• W2023374876 hasConceptScore W2023374876C101762097 @default.
• W2023374876 hasConceptScore W2023374876C104317684 @default.
• W2023374876 hasConceptScore W2023374876C119157956 @default.
• W2023374876 hasConceptScore W2023374876C134320426 @default.
• W2023374876 hasConceptScore W2023374876C149240914 @default.
• W2023374876 hasConceptScore W2023374876C150194340 @default.
• W2023374876 hasConceptScore W2023374876C153911025 @default.
• W2023374876 hasConceptScore W2023374876C185592680 @default.
• W2023374876 hasConceptScore W2023374876C2777865847 @default.
• W2023374876 hasConceptScore W2023374876C2778001298 @default.
• W2023374876 hasConceptScore W2023374876C2778305200 @default.

• next