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- W2023374932 abstract "Considerable evidence accumulated over the past decade has clarified some of the mechanisms of cell-cell interactions in rheumatoid synovitis and the important roles of IL-1 and TNF-α in inflammation and tissue destruction (1, 2). These advances in knowledge have led to the development of novel anticytokine therapies for rheumatoid arthritis (RA). However, in spite of these successes, disagreement remains concerning the relative roles of T cell–dependent versus T cell–independent mechanisms and of IL-1 versus TNF-α in the initiation and perpetuation of rheumatoid synovitis.Studies in experimental animal models of inflammatory arthritis have shed some light on these issues in RA, although it is generally recognized that no animal model is completely equivalent to the human disease. The article by Niki et al. in this issue of the JCI provides some interesting new findings on effects of IL-1 on synovitis (3) and speaks to some of the broader questions regarding the cells and cytokines that drive this disease." @default.
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- W2023374932 title "Cytokines and cellular interactions in inflammatory synovitis" @default.
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- W2023374932 doi "https://doi.org/10.1172/jci12952" @default.
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