FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023375373> ?p ?o ?g. }

• W2023375373 endingPage "239" @default.
• W2023375373 startingPage "229" @default.
• W2023375373 abstract "Abstract. Whilst the potential of gene therapy is considerable, current applications have been restricted by the limitations of available vectors. As yet, no vector is able to produce the desired safe, targeted and efficient transfer of genetic material with regulation of the new gene in the targeted cell. Notwithstanding these limitations, more than 65 clinical gene transfer protocols have been approved in the US. The majority of these are open to patients with malignant disease, in whom the risk: benefit ratio is most appropriate. Current progress and problems in gene transfer are illustrated by reference to gene transfer into haemopoietic stem cells (HSC), an area that has attracted particular attention, both because of the logistic advantages of these cells and because of the wide range of pathologies that may be corrected in the HSC itself or in its progeny. Because of the low efficiency of transfer into HSC, initial studies have involved transfer of marker genes to determine the origin of relapse after autologous bone marrow transplantation and to learn more about the conditions that enhance gene transfer and expression in haemopoietic tissue. Information gained from these studies is already guiding the practice of autologous and allogeneic marrow transplantation and has contributed to the development of gene therapy protocols for the treatment of malignant disease, immune deficiency syndromes and lysosomal storage disorders. Over the next decade, as the technology of gene transfer advances, many further clinical applications of the approach will become evident." @default.
• W2023375373 created "2016-06-24" @default.
• W2023375373 creator A5058287032 @default.
• W2023375373 date "1995-03-01" @default.
• W2023375373 modified "2023-09-23" @default.
• W2023375373 title "Human somatic gene therapy: progress and problems" @default.
• W2023375373 cites W1504458889 @default.
• W2023375373 cites W1970114554 @default.
• W2023375373 cites W1977152358 @default.
• W2023375373 cites W1978416272 @default.
• W2023375373 cites W1989775015 @default.
• W2023375373 cites W1990668606 @default.
• W2023375373 cites W1991148746 @default.
• W2023375373 cites W1992886719 @default.
• W2023375373 cites W2002517161 @default.
• W2023375373 cites W2016176753 @default.
• W2023375373 cites W2016750374 @default.
• W2023375373 cites W2016782363 @default.
• W2023375373 cites W2023555617 @default.
• W2023375373 cites W2026954756 @default.
• W2023375373 cites W2029426142 @default.
• W2023375373 cites W2032524085 @default.
• W2023375373 cites W2037777535 @default.
• W2023375373 cites W2039033043 @default.
• W2023375373 cites W2039825042 @default.
• W2023375373 cites W2048995497 @default.
• W2023375373 cites W2051306981 @default.
• W2023375373 cites W2057436316 @default.
• W2023375373 cites W2062310322 @default.
• W2023375373 cites W2063947819 @default.
• W2023375373 cites W2072002516 @default.
• W2023375373 cites W2083430062 @default.
• W2023375373 cites W2095585128 @default.
• W2023375373 cites W2103872763 @default.
• W2023375373 cites W2110393059 @default.
• W2023375373 cites W2111912711 @default.
• W2023375373 cites W2129851949 @default.
• W2023375373 cites W2132859839 @default.
• W2023375373 cites W2159686532 @default.
• W2023375373 cites W2162992800 @default.
• W2023375373 cites W2259178548 @default.
• W2023375373 cites W2301279425 @default.
• W2023375373 cites W2319128928 @default.
• W2023375373 cites W2324339443 @default.
• W2023375373 cites W2339392195 @default.
• W2023375373 cites W2413746212 @default.
• W2023375373 cites W2416312207 @default.
• W2023375373 cites W30300769 @default.
• W2023375373 cites W4230527064 @default.
• W2023375373 cites W4241664442 @default.
• W2023375373 cites W4245797813 @default.
• W2023375373 cites W4248229196 @default.
• W2023375373 cites W4249432170 @default.
• W2023375373 cites W4253533771 @default.
• W2023375373 doi "https://doi.org/10.1111/j.1365-2796.1995.tb01171.x" @default.
• W2023375373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7891044" @default.
• W2023375373 hasPublicationYear "1995" @default.
• W2023375373 type Work @default.
• W2023375373 sameAs 2023375373 @default.
• W2023375373 citedByCount "37" @default.
• W2023375373 countsByYear W20233753732012 @default.
• W2023375373 countsByYear W20233753732013 @default.
• W2023375373 countsByYear W20233753732016 @default.
• W2023375373 countsByYear W20233753732017 @default.
• W2023375373 countsByYear W20233753732020 @default.
• W2023375373 crossrefType "journal-article" @default.
• W2023375373 hasAuthorship W2023375373A5058287032 @default.
• W2023375373 hasBestOaLocation W20233753731 @default.
• W2023375373 hasConcept C104317684 @default.
• W2023375373 hasConcept C111599444 @default.
• W2023375373 hasConcept C126322002 @default.
• W2023375373 hasConcept C134305767 @default.
• W2023375373 hasConcept C142724271 @default.
• W2023375373 hasConcept C203014093 @default.
• W2023375373 hasConcept C2779134260 @default.
• W2023375373 hasConcept C2780007613 @default.
• W2023375373 hasConcept C28328180 @default.
• W2023375373 hasConcept C2911091166 @default.
• W2023375373 hasConcept C3018928802 @default.
• W2023375373 hasConcept C54355233 @default.
• W2023375373 hasConcept C71924100 @default.
• W2023375373 hasConcept C86803240 @default.
• W2023375373 hasConceptScore W2023375373C104317684 @default.
• W2023375373 hasConceptScore W2023375373C111599444 @default.
• W2023375373 hasConceptScore W2023375373C126322002 @default.
• W2023375373 hasConceptScore W2023375373C134305767 @default.
• W2023375373 hasConceptScore W2023375373C142724271 @default.
• W2023375373 hasConceptScore W2023375373C203014093 @default.
• W2023375373 hasConceptScore W2023375373C2779134260 @default.
• W2023375373 hasConceptScore W2023375373C2780007613 @default.
• W2023375373 hasConceptScore W2023375373C28328180 @default.
• W2023375373 hasConceptScore W2023375373C2911091166 @default.
• W2023375373 hasConceptScore W2023375373C3018928802 @default.
• W2023375373 hasConceptScore W2023375373C54355233 @default.
• W2023375373 hasConceptScore W2023375373C71924100 @default.
• W2023375373 hasConceptScore W2023375373C86803240 @default.
• W2023375373 hasIssue "3" @default.
• W2023375373 hasLocation W20233753731 @default.

• next