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• W2023375857 abstract "Inappropriate activation of the Toll-IL-1R (TL-IL-1) signaling by commensal bacteria contributes to the pathogenesis of inflammatory bowel diseases and colitis-associated cancer. Recent studies have identified SIGIRR as a negative regulator of TL-IL-1 signaling. It dampens intestinal inflammation and tumorigenesis in the colon. In this review, we will discuss the role of SIGIRR in different cell types and the mechanisms underlying its tumor suppressor function." @default.
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• W2023375857 date "2011-12-01" @default.
• W2023375857 modified "2023-09-24" @default.
• W2023375857 title "SIGIRR, a negative regulator of colon tumorigenesis" @default.
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• W2023375857 doi "https://doi.org/10.1016/j.ddmec.2012.02.003" @default.
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