Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023376225> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2023376225 endingPage "165" @default.
- W2023376225 startingPage "153" @default.
- W2023376225 abstract "Endocrine studies, using the four hypothalamic releasing hormones, gonadotrophin releasing hormone, thyrotrophin releasing hormone, corticotrophin releasing hormone and growth hormone releasing hormone, were performed in 33 males after admission with a major head injury. The test was repeated 7 days later in all 33 patients and after 3–6 months in 21 patients. All patients had a period of unconsciousness followed by post-traumatic amnesia of greater than 24 h. The results obtained from investigating the gonadal axis are reported in this paper. The levels of total and free testosterone, basal FSH and basal LH fell significantly during the first 3 days after injury, when the LH and FSH responses to GnRH achieved their highest peak levels. This hormone pattern has not previously been reported in the gonadal axis and may be a consequence of hypothalamic dysfunction. The severity of the injury was negatively correlated to the testosterone concentration on admission and to the basal and peak FSH concentrations 1 week later. Persistent hypogonadism was found in five of the 21 patients retested after 3–6 months, with low testosterone concentrations and three continued to have an exaggerated LH response to GnRH. Thus major head injury frequently results in hypogonadism shortly after injury, with an increased gonadotrophin response to GnRH. In addition, a substantial minority of patients continue to be hypogonadal after 3–6 months. In view of these findings we strongly suggest that all patients should be endocrinologically assessed at intervals following severe head injury." @default.
- W2023376225 created "2016-06-24" @default.
- W2023376225 creator A5017701312 @default.
- W2023376225 creator A5068833829 @default.
- W2023376225 creator A5089706998 @default.
- W2023376225 date "1988-08-01" @default.
- W2023376225 modified "2023-09-23" @default.
- W2023376225 title "HYPOTHALAMIC HYPOGONADISM FOLLOWING MAJOR HEAD INJURY" @default.
- W2023376225 cites W1603121691 @default.
- W2023376225 cites W1982881303 @default.
- W2023376225 cites W1989357421 @default.
- W2023376225 cites W2002200973 @default.
- W2023376225 cites W2003515127 @default.
- W2023376225 cites W2005269436 @default.
- W2023376225 cites W2006211976 @default.
- W2023376225 cites W2044202413 @default.
- W2023376225 cites W2067943766 @default.
- W2023376225 cites W2070292680 @default.
- W2023376225 cites W2070398372 @default.
- W2023376225 cites W2083605422 @default.
- W2023376225 cites W2084417111 @default.
- W2023376225 cites W2094658938 @default.
- W2023376225 cites W2098389360 @default.
- W2023376225 cites W2117641329 @default.
- W2023376225 cites W2118910616 @default.
- W2023376225 cites W2143468403 @default.
- W2023376225 cites W2146726086 @default.
- W2023376225 cites W4293589010 @default.
- W2023376225 cites W4299612197 @default.
- W2023376225 doi "https://doi.org/10.1111/j.1365-2265.1988.tb00257.x" @default.
- W2023376225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3150320" @default.
- W2023376225 hasPublicationYear "1988" @default.
- W2023376225 type Work @default.
- W2023376225 sameAs 2023376225 @default.
- W2023376225 citedByCount "50" @default.
- W2023376225 countsByYear W20233762252012 @default.
- W2023376225 countsByYear W20233762252015 @default.
- W2023376225 countsByYear W20233762252016 @default.
- W2023376225 countsByYear W20233762252017 @default.
- W2023376225 countsByYear W20233762252019 @default.
- W2023376225 countsByYear W20233762252021 @default.
- W2023376225 crossrefType "journal-article" @default.
- W2023376225 hasAuthorship W2023376225A5017701312 @default.
- W2023376225 hasAuthorship W2023376225A5068833829 @default.
- W2023376225 hasAuthorship W2023376225A5089706998 @default.
- W2023376225 hasConcept C126322002 @default.
- W2023376225 hasConcept C134018914 @default.
- W2023376225 hasConcept C141071460 @default.
- W2023376225 hasConcept C2776470351 @default.
- W2023376225 hasConcept C2777975874 @default.
- W2023376225 hasConcept C2778024521 @default.
- W2023376225 hasConcept C2778575703 @default.
- W2023376225 hasConcept C2778894405 @default.
- W2023376225 hasConcept C2779279991 @default.
- W2023376225 hasConcept C2779306644 @default.
- W2023376225 hasConcept C42219234 @default.
- W2023376225 hasConcept C46699223 @default.
- W2023376225 hasConcept C71315377 @default.
- W2023376225 hasConcept C71924100 @default.
- W2023376225 hasConceptScore W2023376225C126322002 @default.
- W2023376225 hasConceptScore W2023376225C134018914 @default.
- W2023376225 hasConceptScore W2023376225C141071460 @default.
- W2023376225 hasConceptScore W2023376225C2776470351 @default.
- W2023376225 hasConceptScore W2023376225C2777975874 @default.
- W2023376225 hasConceptScore W2023376225C2778024521 @default.
- W2023376225 hasConceptScore W2023376225C2778575703 @default.
- W2023376225 hasConceptScore W2023376225C2778894405 @default.
- W2023376225 hasConceptScore W2023376225C2779279991 @default.
- W2023376225 hasConceptScore W2023376225C2779306644 @default.
- W2023376225 hasConceptScore W2023376225C42219234 @default.
- W2023376225 hasConceptScore W2023376225C46699223 @default.
- W2023376225 hasConceptScore W2023376225C71315377 @default.
- W2023376225 hasConceptScore W2023376225C71924100 @default.
- W2023376225 hasIssue "2" @default.
- W2023376225 hasLocation W20233762251 @default.
- W2023376225 hasLocation W20233762252 @default.
- W2023376225 hasOpenAccess W2023376225 @default.
- W2023376225 hasPrimaryLocation W20233762251 @default.
- W2023376225 hasRelatedWork W1541445894 @default.
- W2023376225 hasRelatedWork W1988486434 @default.
- W2023376225 hasRelatedWork W2012502375 @default.
- W2023376225 hasRelatedWork W2025304600 @default.
- W2023376225 hasRelatedWork W2036239614 @default.
- W2023376225 hasRelatedWork W2047880909 @default.
- W2023376225 hasRelatedWork W2057000165 @default.
- W2023376225 hasRelatedWork W2061429954 @default.
- W2023376225 hasRelatedWork W2064034534 @default.
- W2023376225 hasRelatedWork W2410500319 @default.
- W2023376225 hasVolume "29" @default.
- W2023376225 isParatext "false" @default.
- W2023376225 isRetracted "false" @default.
- W2023376225 magId "2023376225" @default.
- W2023376225 workType "article" @default.