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- W2023376917 abstract "Abstract Ligand‐stabilized copper(I)–hydride catalyzes the dehydrogenative Si–O coupling of alcohols and silanes—a process that was found to proceed without racemization at the silicon atom if asymmetrically substituted. The present investigation starts from this pivotal observation since silicon‐stereogenic silanes are thereby suitable for the reagent‐controlled kinetic resolution of racemic alcohols, in which asymmetry at the silicon atom enables discrimination of enantiomeric alcohols. In this full account, we summarize our efforts to systematically examine this unusual strategy of diastereoselective alcohol silylation. Ligand (sufficient reactivity with moderately electron‐rich monophosphines), silane (reasonable diastereocontrol with cyclic silanes having a distinct substitution pattern) as well as substrate identification (chelating donor as a requirement) are introductorily described. With these basic data at hand, the substrate scope was defined employing enantiomerically enriched tert ‐butyl‐substituted 1‐silatetraline and highly reactive 1‐silaindane. The synthetic part is complemented by the determination of the stereochemical course at the silicon atom in the Si–O coupling step followed by its quantum‐chemical analysis thus providing a solid mechanistic picture of this remarkable transformation." @default.
- W2023376917 created "2016-06-24" @default.
- W2023376917 creator A5002792140 @default.
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- W2023376917 creator A5042863303 @default.
- W2023376917 creator A5068255765 @default.
- W2023376917 creator A5090088618 @default.
- W2023376917 date "2008-12-12" @default.
- W2023376917 modified "2023-10-18" @default.
- W2023376917 title "Stereoselective Alcohol Silylation by Dehydrogenative Si-O Coupling: Scope, Limitations, and Mechanism of the Cu-H-Catalyzed Non-Enzymatic Kinetic Resolution with Silicon-Stereogenic Silanes" @default.
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- W2023376917 doi "https://doi.org/10.1002/chem.200801377" @default.
- W2023376917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19021177" @default.
- W2023376917 hasPublicationYear "2008" @default.
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