FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023377074> ?p ?o ?g. }

• W2023377074 endingPage "143" @default.
• W2023377074 startingPage "133" @default.
• W2023377074 abstract "Gram-positive bacterial cell wall components including PGN (peptidoglycan) elicit a potent pro-inflammatory response in diverse cell types, including endothelial cells, by activating TLR2 (Toll-like receptor 2) signalling. The functional integrity of the endothelium is under the influence of a network of gap junction intercellular communication channels composed of Cxs (connexins) that also form hemichannels, signalling conduits that are implicated in ATP release and purinergic signalling. PGN modulates Cx expression in a variety of cell types, yet effects in endothelial cells remain unresolved. Using the endothelial cell line b.End5, a 6 h challenge with PGN induced IL-6 (interleukin 6), TLR2 and Cx43 mRNA expression that was associated with enhanced Cx43 protein expression and gap junction coupling. Cx43 hemichannel activity, measured by ATP release from the cells, was induced following 15 min of exposure to PGN. Inhibition of hemichannel activity with carbenoxolone or apyrase prevented induction of IL-6 and TLR2 mRNA expression by PGN, but had no effect on Cx43 mRNA expression levels. In contrast, knockdown of TLR2 expression had no effect on PGN-induced hemichannel activity, but reduced the level of TLR2 and Cx43 mRNA expression following 6 h of PGN challenge. PGN also acutely induced hemichannel activity in HeLa cells transfected to express Cx43, but had no effect in Cx43-deficient HeLa OHIO cells. All ATP responses were blocked with Cx-specific channel blockers. We conclude that acute Cx43 hemichannel signalling plays a role in the initiation of early innate immune responses in the endothelium." @default.
• W2023377074 created "2016-06-24" @default.
• W2023377074 creator A5015256941 @default.
• W2023377074 creator A5075936035 @default.
• W2023377074 creator A5086612993 @default.
• W2023377074 creator A5087083827 @default.
• W2023377074 date "2010-10-25" @default.
• W2023377074 modified "2023-09-23" @default.
• W2023377074 title "Peptidoglycan derived from <i>Staphylococcus epidermidis</i> induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells" @default.
• W2023377074 cites W1486819284 @default.
• W2023377074 cites W1573567421 @default.
• W2023377074 cites W1821774298 @default.
• W2023377074 cites W1846377272 @default.
• W2023377074 cites W1977884112 @default.
• W2023377074 cites W1978254950 @default.
• W2023377074 cites W1984604492 @default.
• W2023377074 cites W1984634028 @default.
• W2023377074 cites W1992576846 @default.
• W2023377074 cites W2000365029 @default.
• W2023377074 cites W2011498170 @default.
• W2023377074 cites W2013736577 @default.
• W2023377074 cites W2016263791 @default.
• W2023377074 cites W2019015469 @default.
• W2023377074 cites W2022398923 @default.
• W2023377074 cites W2026761520 @default.
• W2023377074 cites W2033803440 @default.
• W2023377074 cites W2034465562 @default.
• W2023377074 cites W2036455407 @default.
• W2023377074 cites W2036553406 @default.
• W2023377074 cites W2041758632 @default.
• W2023377074 cites W2042229346 @default.
• W2023377074 cites W2046207517 @default.
• W2023377074 cites W2055873529 @default.
• W2023377074 cites W2057201236 @default.
• W2023377074 cites W2069144706 @default.
• W2023377074 cites W2070872027 @default.
• W2023377074 cites W2074389121 @default.
• W2023377074 cites W2076273115 @default.
• W2023377074 cites W2083119828 @default.
• W2023377074 cites W2085780740 @default.
• W2023377074 cites W2087917186 @default.
• W2023377074 cites W2088631191 @default.
• W2023377074 cites W2089380385 @default.
• W2023377074 cites W2094332218 @default.
• W2023377074 cites W2096029601 @default.
• W2023377074 cites W2104001632 @default.
• W2023377074 cites W2105392170 @default.
• W2023377074 cites W2117926778 @default.
• W2023377074 cites W2123968620 @default.
• W2023377074 cites W2126552441 @default.
• W2023377074 cites W2127092524 @default.
• W2023377074 cites W2134858220 @default.
• W2023377074 cites W2135446158 @default.
• W2023377074 cites W2138046394 @default.
• W2023377074 cites W2139585490 @default.
• W2023377074 cites W2148018148 @default.
• W2023377074 cites W2148038959 @default.
• W2023377074 cites W2150002190 @default.
• W2023377074 cites W2152266406 @default.
• W2023377074 cites W2162513556 @default.
• W2023377074 cites W2373352946 @default.
• W2023377074 cites W4256529798 @default.
• W2023377074 doi "https://doi.org/10.1042/bj20091753" @default.
• W2023377074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20815816" @default.
• W2023377074 hasPublicationYear "2010" @default.
• W2023377074 type Work @default.
• W2023377074 sameAs 2023377074 @default.
• W2023377074 citedByCount "56" @default.
• W2023377074 countsByYear W20233770742012 @default.
• W2023377074 countsByYear W20233770742013 @default.
• W2023377074 countsByYear W20233770742014 @default.
• W2023377074 countsByYear W20233770742015 @default.
• W2023377074 countsByYear W20233770742016 @default.
• W2023377074 countsByYear W20233770742017 @default.
• W2023377074 countsByYear W20233770742018 @default.
• W2023377074 countsByYear W20233770742019 @default.
• W2023377074 countsByYear W20233770742020 @default.
• W2023377074 countsByYear W20233770742021 @default.
• W2023377074 countsByYear W20233770742023 @default.
• W2023377074 crossrefType "journal-article" @default.
• W2023377074 hasAuthorship W2023377074A5015256941 @default.
• W2023377074 hasAuthorship W2023377074A5075936035 @default.
• W2023377074 hasAuthorship W2023377074A5086612993 @default.
• W2023377074 hasAuthorship W2023377074A5087083827 @default.
• W2023377074 hasBestOaLocation W20233770742 @default.
• W2023377074 hasConcept C123012128 @default.
• W2023377074 hasConcept C134018914 @default.
• W2023377074 hasConcept C136449434 @default.
• W2023377074 hasConcept C158157758 @default.
• W2023377074 hasConcept C170493617 @default.
• W2023377074 hasConcept C201685922 @default.
• W2023377074 hasConcept C202751555 @default.
• W2023377074 hasConcept C2776070231 @default.
• W2023377074 hasConcept C2776992346 @default.
• W2023377074 hasConcept C2780228694 @default.
• W2023377074 hasConcept C2780961449 @default.
• W2023377074 hasConcept C2781236682 @default.
• W2023377074 hasConcept C28406088 @default.

• next