Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023379699> ?p ?o ?g. }
- W2023379699 endingPage "309" @default.
- W2023379699 startingPage "304" @default.
- W2023379699 abstract "Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protects organisms against oxidative damage, dismutating superoxide radical (O₂(.)⁻) into H₂O₂ and O₂. The active site of the protein presents a Mn ion in a distorted trigonal-bipyramidal environment, coordinated by H26, H74, H163, D159 and one ⁻OH ion or H₂O molecule. The catalytic cycle of the enzyme is a ping-pong mechanism involving Mn³+/Mn²+. It is known that nitration of Y34 is responsible for enzyme inactivation, and that this protein oxidative modification is found in tissues undergoing inflammatory and degenerative processes. However, the molecular basis about MnSOD tyrosine nitration affects the protein catalytic function is mostly unknown. In this work we strongly suggest, using computer simulation tools, that Y34 nitration affects protein function by restricting ligand access to the active site. In particular, deprotonation of 3-nitrotyrosine increases drastically the energetic barrier for ligand entry due to the absence of the proton. Our results for the WT and selected mutant proteins confirm that the phenolic moiety of Y34 plays a key role in assisting superoxide migration." @default.
- W2023379699 created "2016-06-24" @default.
- W2023379699 creator A5006706014 @default.
- W2023379699 creator A5019388904 @default.
- W2023379699 creator A5027286823 @default.
- W2023379699 creator A5027457760 @default.
- W2023379699 creator A5057502709 @default.
- W2023379699 creator A5073926538 @default.
- W2023379699 creator A5089022257 @default.
- W2023379699 date "2011-03-01" @default.
- W2023379699 modified "2023-10-16" @default.
- W2023379699 title "Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration" @default.
- W2023379699 cites W1497458285 @default.
- W2023379699 cites W1877598426 @default.
- W2023379699 cites W1967252819 @default.
- W2023379699 cites W1969941249 @default.
- W2023379699 cites W1972295809 @default.
- W2023379699 cites W1975952514 @default.
- W2023379699 cites W1976161355 @default.
- W2023379699 cites W1976499671 @default.
- W2023379699 cites W1987903324 @default.
- W2023379699 cites W1997382584 @default.
- W2023379699 cites W1999649376 @default.
- W2023379699 cites W2002228166 @default.
- W2023379699 cites W2003108616 @default.
- W2023379699 cites W2005381951 @default.
- W2023379699 cites W2009279488 @default.
- W2023379699 cites W2011552468 @default.
- W2023379699 cites W2017758139 @default.
- W2023379699 cites W2020539703 @default.
- W2023379699 cites W2022458326 @default.
- W2023379699 cites W2024994588 @default.
- W2023379699 cites W2038284767 @default.
- W2023379699 cites W2039626545 @default.
- W2023379699 cites W2045349837 @default.
- W2023379699 cites W2046543299 @default.
- W2023379699 cites W2052562838 @default.
- W2023379699 cites W2055765410 @default.
- W2023379699 cites W2056056789 @default.
- W2023379699 cites W2056748221 @default.
- W2023379699 cites W2067017706 @default.
- W2023379699 cites W2069053623 @default.
- W2023379699 cites W2076828323 @default.
- W2023379699 cites W2078672958 @default.
- W2023379699 cites W2080432090 @default.
- W2023379699 cites W2090134780 @default.
- W2023379699 cites W2093212227 @default.
- W2023379699 cites W2093381148 @default.
- W2023379699 cites W2094655287 @default.
- W2023379699 cites W2095450601 @default.
- W2023379699 cites W2109069085 @default.
- W2023379699 cites W2112862672 @default.
- W2023379699 cites W2114443210 @default.
- W2023379699 cites W2119547158 @default.
- W2023379699 cites W2128022125 @default.
- W2023379699 cites W2142362661 @default.
- W2023379699 cites W2148557032 @default.
- W2023379699 cites W2149801992 @default.
- W2023379699 cites W2150916538 @default.
- W2023379699 cites W2158785350 @default.
- W2023379699 cites W2168327701 @default.
- W2023379699 cites W2270686920 @default.
- W2023379699 cites W2274171250 @default.
- W2023379699 doi "https://doi.org/10.1016/j.abb.2010.12.011" @default.
- W2023379699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21167124" @default.
- W2023379699 hasPublicationYear "2011" @default.
- W2023379699 type Work @default.
- W2023379699 sameAs 2023379699 @default.
- W2023379699 citedByCount "47" @default.
- W2023379699 countsByYear W20233796992012 @default.
- W2023379699 countsByYear W20233796992013 @default.
- W2023379699 countsByYear W20233796992014 @default.
- W2023379699 countsByYear W20233796992015 @default.
- W2023379699 countsByYear W20233796992016 @default.
- W2023379699 countsByYear W20233796992017 @default.
- W2023379699 countsByYear W20233796992018 @default.
- W2023379699 countsByYear W20233796992019 @default.
- W2023379699 countsByYear W20233796992020 @default.
- W2023379699 countsByYear W20233796992021 @default.
- W2023379699 countsByYear W20233796992022 @default.
- W2023379699 countsByYear W20233796992023 @default.
- W2023379699 crossrefType "journal-article" @default.
- W2023379699 hasAuthorship W2023379699A5006706014 @default.
- W2023379699 hasAuthorship W2023379699A5019388904 @default.
- W2023379699 hasAuthorship W2023379699A5027286823 @default.
- W2023379699 hasAuthorship W2023379699A5027457760 @default.
- W2023379699 hasAuthorship W2023379699A5057502709 @default.
- W2023379699 hasAuthorship W2023379699A5073926538 @default.
- W2023379699 hasAuthorship W2023379699A5089022257 @default.
- W2023379699 hasBestOaLocation W20233796992 @default.
- W2023379699 hasConcept C116569031 @default.
- W2023379699 hasConcept C170493617 @default.
- W2023379699 hasConcept C178790620 @default.
- W2023379699 hasConcept C181199279 @default.
- W2023379699 hasConcept C185592680 @default.
- W2023379699 hasConcept C2775838275 @default.
- W2023379699 hasConcept C2775856698 @default.
- W2023379699 hasConcept C2776165026 @default.