FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023380764> ?p ?o ?g. }

• W2023380764 endingPage "1055" @default.
• W2023380764 startingPage "1043" @default.
• W2023380764 abstract "Translocation of bacteria and their products across the intestinal barrier is common in patients with liver disease, and there is evidence that experimental liver fibrosis depends on bacterial translocation. The purpose of our study was to investigate liver fibrosis in conventional and germ-free (GF) C57BL/6 mice. Chronic liver injury was induced by administration of thioacetamide (TAA) in the drinking water for 21 wk or by repeated intraperitoneal injections of carbon tetrachloride (CCl4). Increased liver fibrosis was observed in GF mice compared with conventional mice. Hepatocytes showed more toxin-induced oxidative stress and cell death. This was accompanied by increased activation of hepatic stellate cells, but hepatic mediators of inflammation were not significantly different. Similarly, a genetic model using Myd88/Trif-deficient mice, which lack downstream innate immunity signaling, had more severe fibrosis than wild-type mice. Isolated Myd88/Trif-deficient hepatocytes were more susceptible to toxin-induced cell death in culture. In conclusion, the commensal microbiota prevents fibrosis upon chronic liver injury in mice. This is the first study describing a beneficial role of the commensal microbiota in maintaining liver homeostasis and preventing liver fibrosis." @default.
• W2023380764 created "2016-06-24" @default.
• W2023380764 creator A5000702539 @default.
• W2023380764 creator A5001918029 @default.
• W2023380764 creator A5007057003 @default.
• W2023380764 creator A5007202760 @default.
• W2023380764 creator A5007415599 @default.
• W2023380764 creator A5041372600 @default.
• W2023380764 creator A5058796422 @default.
• W2023380764 creator A5067217335 @default.
• W2023380764 creator A5077627182 @default.
• W2023380764 creator A5084545012 @default.
• W2023380764 creator A5086552164 @default.
• W2023380764 creator A5087817221 @default.
• W2023380764 creator A5091812870 @default.
• W2023380764 date "2014-12-02" @default.
• W2023380764 modified "2023-10-14" @default.
• W2023380764 title "Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice" @default.
• W2023380764 cites W1968460020 @default.
• W2023380764 cites W1969579498 @default.
• W2023380764 cites W1975691929 @default.
• W2023380764 cites W1976134680 @default.
• W2023380764 cites W1983778185 @default.
• W2023380764 cites W1987291131 @default.
• W2023380764 cites W1988039243 @default.
• W2023380764 cites W1988990189 @default.
• W2023380764 cites W1994348473 @default.
• W2023380764 cites W1995744610 @default.
• W2023380764 cites W1995878063 @default.
• W2023380764 cites W1998644615 @default.
• W2023380764 cites W2008086832 @default.
• W2023380764 cites W2010042337 @default.
• W2023380764 cites W2012490955 @default.
• W2023380764 cites W2013101192 @default.
• W2023380764 cites W2014185375 @default.
• W2023380764 cites W2018346422 @default.
• W2023380764 cites W2020219616 @default.
• W2023380764 cites W2024766244 @default.
• W2023380764 cites W2027187941 @default.
• W2023380764 cites W2027581246 @default.
• W2023380764 cites W2027968599 @default.
• W2023380764 cites W2037108200 @default.
• W2023380764 cites W2039088885 @default.
• W2023380764 cites W2040804852 @default.
• W2023380764 cites W2040874707 @default.
• W2023380764 cites W2043180366 @default.
• W2023380764 cites W2045358375 @default.
• W2023380764 cites W2056136212 @default.
• W2023380764 cites W2057835131 @default.
• W2023380764 cites W2070352246 @default.
• W2023380764 cites W2072398980 @default.
• W2023380764 cites W2075363951 @default.
• W2023380764 cites W2077790453 @default.
• W2023380764 cites W2084830964 @default.
• W2023380764 cites W2088697466 @default.
• W2023380764 cites W2103431821 @default.
• W2023380764 cites W2103456695 @default.
• W2023380764 cites W2104890139 @default.
• W2023380764 cites W2105900654 @default.
• W2023380764 cites W2108155566 @default.
• W2023380764 cites W2109943841 @default.
• W2023380764 cites W2129208824 @default.
• W2023380764 cites W2131157225 @default.
• W2023380764 cites W2132692852 @default.
• W2023380764 cites W2136211803 @default.
• W2023380764 cites W2138608324 @default.
• W2023380764 cites W2138801049 @default.
• W2023380764 cites W2141158324 @default.
• W2023380764 cites W2144275312 @default.
• W2023380764 cites W2147786790 @default.
• W2023380764 cites W2153223490 @default.
• W2023380764 cites W2155112010 @default.
• W2023380764 cites W2155897723 @default.
• W2023380764 cites W2157350742 @default.
• W2023380764 cites W2158286355 @default.
• W2023380764 cites W2159147497 @default.
• W2023380764 cites W2163489226 @default.
• W2023380764 cites W2164906049 @default.
• W2023380764 cites W2164995080 @default.
• W2023380764 cites W2169794895 @default.
• W2023380764 cites W2178044610 @default.
• W2023380764 cites W2328023807 @default.
• W2023380764 cites W2396771173 @default.
• W2023380764 doi "https://doi.org/10.1096/fj.14-259515" @default.
• W2023380764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4422368" @default.
• W2023380764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25466902" @default.
• W2023380764 hasPublicationYear "2014" @default.
• W2023380764 type Work @default.
• W2023380764 sameAs 2023380764 @default.
• W2023380764 citedByCount "144" @default.
• W2023380764 countsByYear W20233807642015 @default.
• W2023380764 countsByYear W20233807642016 @default.
• W2023380764 countsByYear W20233807642017 @default.
• W2023380764 countsByYear W20233807642018 @default.
• W2023380764 countsByYear W20233807642019 @default.
• W2023380764 countsByYear W20233807642020 @default.
• W2023380764 countsByYear W20233807642021 @default.
• W2023380764 countsByYear W20233807642022 @default.

• next